{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:11:56Z","timestamp":1790979116961,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA035482"],"award-info":[{"award-number":["R01 DA035482"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA035281"],"award-info":[{"award-number":["R01 DA035281"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R44 DA041967"],"award-info":[{"award-number":["R44 DA041967"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>\n                      Adolescents are regularly exposed to \u2206\n                      <jats:sup>9<\/jats:sup>\n                      \u2010tetrahydrocannabinol (THC) via smoking and, more recently, vaping cannabis extracts. Growing legalization of cannabis for medical and recreational purposes, combined with decreasing perceptions of harm, makes it increasingly important to determine the consequences of frequent adolescent exposure for motivated behaviour and lasting tolerance in response to THC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approaches<\/jats:title>\n                    <jats:p>Male and female rats inhaled THC vapour, or that from the propylene glycol (PG) vehicle, twice daily for 30\u00a0min from postnatal day (PND) 35\u201339 and PND 42\u201346 using an e\u2010cigarette system. Thermoregulatory responses to vapour inhalation were assessed by radio\u2010telemetry during adolescence and from PND 86\u201394. Chow intake was assessed in adulthood. Blood samples were obtained from additional adolescent groups following initial THC inhalation and after 4\u00a0days of twice daily exposure. Additional groups exposed repeatedly to THC or PG during adolescence were evaluated for intravenous self\u2010administration of oxycodone as adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Female, not male, adolescents developed tolerance to the hypothermic effects of THC inhalation in the first week of repeated exposure despite similar plasma THC levels. Each sex exhibited tolerance to THC hypothermia in adulthood after repeated adolescent THC. However, enhanced potency was found in females. Repeated THC male rats consumed more food than their PG\u2010treated control group, without significant bodyweight differences. Adolescent THC did not alter oxycodone self\u2010administration in either sex but increased fentanyl self\u2010administration in females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Repeated THC vapour inhalation in adolescent rats has lasting consequences observable in adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14856","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T06:43:57Z","timestamp":1567493037000},"page":"188-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Lasting effects of repeated \u2206\n                    <scp>\n                      <sup>9<\/sup>\n                    <\/scp>\n                    \u2010tetrahydrocannabinol vapour inhalation during adolescence in male and female rats"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0397-0582","authenticated-orcid":false,"given":"Jacques D.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla California"},{"name":"Department of Psychiatry University of California  La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Creehan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla California"},{"name":"Department of Psychiatry University of California  La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony M.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-1738","authenticated-orcid":false,"given":"Michael A.","family":"Taffe","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Scripps Research Institute  La Jolla California"},{"name":"Department of Psychiatry University of California  La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12038"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2017.10.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13878"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.08.002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1318-z"},{"key":"e_1_2_11_7_1","article-title":"Role of mu, but not \u2206 or \u03ba, opioid receptors in context\u2010induced reinstatement of oxycodone seeking","author":"Bossert J. 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