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Validated biomarkers enhance efforts for early detection and treatment, which reduce the risk of mortality. Epigenetic signatures have been suggested as good biomarkers for early detection, prognosis and targeted therapy of BC. Here, we highlight studies documenting the modifying effects of dietary fatty acids and obesity on BC biomarkers associated with DNA methylation. We focus our analysis on changes elicited in writers of DNA methylation (i.e., DNA methyltransferases), global DNA methylation and gene\u2010specific DNA methylation. To provide context, we precede this discussion with a review of the available evidence for an association between BC incidence and both dietary fat consumption and obesity. We also include a review of well\u2010vetted BC biomarkers related to cytosine\u2010guanine dinucleotides methylation and how they influence BC risk, prognosis, tumour characteristics and response to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.6\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.6\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.14891","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T05:24:21Z","timestamp":1573017861000},"page":"1331-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation"],"prefix":"10.1111","volume":"177","author":[{"given":"Micah G.","family":"Donovan","sequence":"first","affiliation":[{"name":"Interdisciplinary Cancer Biology Graduate Program University of Arizona  Tucson Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer 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