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However, little is known about the long\u2010term consequences of cocaine use and abuse in individuals with FASD. This study aimed to investigate the effects of maternal binge alcohol drinking during prenatal and postnatal periods on cocaine reward\u2010related behaviours in adult offspring.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Pregnant C57BL\/6 female mice were exposed to an experimental protocol of binge alcohol consumption (drinking\u2010in\u2010the\u2010dark test) from gestation to weaning. Male offspring were subsequently left undisturbed until reaching adulthood and were tested for cocaine\u2010induced motivational responses (conditioned place preference, behavioural sensitization and operant self\u2010administration). Protein expression of dopamine\u2010 and glutamate\u2010related molecules was assessed following cocaine\u2010induced reinstatement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>The results show that prenatal and postnatal alcohol exposure enhanced the preference for the cocaine\u2010paired chamber in the conditioned place preference test. Furthermore, early alcohol\u2010exposed mice displayed attenuated cocaine\u2010induced behavioural sensitization but also higher cocaine self\u2010administration. Furthermore, alterations in glutamatergic excitability (GluA1\/GluA2 ratio) and \u0394FosB expression were found in the prefrontal cortex and the striatum of alcohol\u2010exposed mice after cocaine\u2010primed reinstatement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>Our findings demonstrate that maternal binge\u2010like alcohol consumption during gestation and lactation alters sensitivity to the reinforcing effects of cocaine in adult offspring mice. Together, such data suggest that prenatal and postnatal alcohol exposure may underlie an enhanced susceptibility of alcohol\u2010exposed offspring to develop drug addiction later in adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14901","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T21:27:55Z","timestamp":1573248475000},"page":"1090-1105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prenatal and postnatal alcohol exposure increases vulnerability to cocaine addiction in adult mice"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-8777","authenticated-orcid":false,"given":"L\u00eddia","family":"Cantacorps","sequence":"first","affiliation":[{"name":"Neurobiology of Behaviour Research Group (GReNeC\u2010NeuroBio), Department of Experimental and Health Sciences Universitat Pompeu Fabra  Barcelona 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