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Here, we have evaluated the anti\u2010tremor activity of memantine, \u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol (THC) given alone and of their combination. The involvement of some neuroanatomical structures in the effects of the combination was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Haloperidol\u2010induced tremulous jaw movements (TJMs) in rats were used as a model of parkinsonian\u2010like tremor. To evaluate the role of central receptor systems in the drug effects, receptor ligands were administered locally into certain brain areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Memantine and THC alone were without effect, although co\u2010administration of these drugs decreased the number of haloperidol\u2010induced jaw movements. The anti\u2010tremor activity of the combination was antagonized (a) by injections of <jats:sc>l<\/jats:sc>\u2010glutamate into the dorsal striatum, entopeduncular nucleus, substantia nigra pars reticulata, globus pallidus, and supratrigeminal and trigeminal motor nuclei but not into the subthalamic and cuneiform nuclei; (b) by injections of CGS 21680 into the ventrolateral striatum; and (c) by injections of bicuculline into the rostral part of the parvicellular reticular nucleus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>Memantine and THC supra\u2010additively inhibit haloperidol\u2010induced TJMs, suggesting that co\u2010administration of these drugs might be a new approach to the treatment of tremor. Our results identified brain areas influencing parkinsonian\u2010like tremor in rats and can help advance the development of novel treatments for repetitive involuntary movements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.14914","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T03:59:57Z","timestamp":1573099197000},"page":"1514-1524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Expression of Concern: Neuroanatomical correlates of the inhibition of tremulous jaw movements in rats by a combination of memantine and \u0394<sup>9<\/sup>\u2010tetrahydrocannabinol"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1556-6707","authenticated-orcid":false,"given":"Ilya D.","family":"Ionov","sequence":"first","affiliation":[{"name":"Centre on Theoretical Problems in Physical and Chemical Pharmacology Russian Academy of Sciences  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina I.","family":"Pushinskaya","sequence":"additional","affiliation":[{"name":"Division of Neurodegeneration Timpharm LTD  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Frenkel","sequence":"additional","affiliation":[{"name":"Division of Neurodegeneration Timpharm LTD  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni\u0441holas P.","family":"Gorev","sequence":"additional","affiliation":[{"name":"Division of Neurodegeneration Timpharm LTD  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa A.","family":"Shpilevaya","sequence":"additional","affiliation":[{"name":"Division of Neurodegeneration Timpharm LTD  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90074-X"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14748"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14749"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(79)90402-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10482"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903210312"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.02.003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-35-11073.2003"},{"issue":"5","key":"e_1_2_11_10_1","first-page":"809","article-title":"The antihyperalgic effect of memantine in a rat model of paclitaxel induced neuropathic pain","volume":"64","author":"Ciotu I. 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