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Here, we have assessed the potential therapeutic effects of donecopride in treating Alzheimer's disease (AD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>We used two in vivo animal models of AD, transgenic 5XFAD mice and mice exposed to soluble amyloid\u2010\u03b2 peptides and, in vitro, primary cultures of rat hippocampal neurons. Pro\u2010cognitive and anti\u2010amnesic effects were evaluated with novel object recognition, Y\u2010maze, and Morris water maze tests. Amyloid load in mouse brain was measured ex vivo and effects of soluble amyloid\u2010\u03b2 peptides on neuronal survival and neurite formation determined in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>In vivo, chronic (3 months) administration of donecopride displayed potent anti\u2010amnesic properties in the two mouse models of AD, preserving learning capacities, including working and long\u2010term spatial memories. These behavioural effects were accompanied by decreased amyloid aggregation in the brain of 5XFAD mice and, in cultures of rat hippocampal neurons, reduced tau hyperphosphorylation. In vitro, donecopride increased survival in neuronal cultures exposed to soluble amyloid\u2010\u03b2 peptides, improved the neurite network and provided neurotrophic benefits, expressed as the formation of new synapses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Donecopride acts like a Swiss army knife, exhibiting a range of sustainable symptomatic therapeutic effects and potential disease\u2010modifying effects in models of AD. Clinical trials with this promising drug candidate will soon be undertaken to confirm its therapeutic potential in humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14964","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T19:03:44Z","timestamp":1577473424000},"page":"1988-2005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Donecopride, a Swiss army knife with potential against Alzheimer's disease"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7996-2082","authenticated-orcid":false,"given":"Christophe","family":"Rochais","sequence":"first","affiliation":[{"name":"Normandie Univ  Caen France"},{"name":"UNICAEN CERMN (Centre d'Etudes et de Recherche sur le M\u00e9dicament de Normandie)  Caen 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