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Eucalyptol (1,8\u2010cineol), the principal component in the essential oils of eucalyptus leaves, is known to possess anti\u2010inflammatory and analgesic properties. We aimed to examine the therapeutic effects of eucalyptol on gout arthritis and related mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>A mouse model of gout arthritis was established via MSU injection into the ankle joint. Ankle oedema, mechanical allodynia, neutrophil infiltration, oxidative stress, NLRP3 inflammasome, and TRPV1 expression were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Eucalyptol attenuated MSU\u2010induced mechanical allodynia and ankle oedema in dose\u2010dependently, with effectiveness similar to indomethacin. Eucalyptol reduced inflammatory cell infiltrations in ankle tissues. Eucalyptol inhibited NLRP3 inflammasome activation and pro\u2010inflammatory cytokine production induced by MSU in ankle tissues in vivo. Eucalyptol reduced oxidative stress induced by MSU in RAW264.7 cells in vitro as well as in ankle tissues in vivo, indicated by an increase in activities of antioxidant enzymes and reduction of ROS. Eucalyptol attenuated MSU\u2010induced up\u2010regulation of TRPV1 expression in ankle tissues and dorsal root ganglion neurons innervating the ankle. The in vivo effects of eucalyptol on ankle oedema, mechanical allodynia, NLRP3 inflammasome, IL\u20101\u03b2, and TRPV1 expression were mimicked by treating MSU\u2010injected mice with antioxidants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>Eucalyptol alleviates MSU\u2010induced pain and inflammation via mechanisms possibly involving anti\u2010oxidative effect. Eucalyptol and other antioxidants may represent promising therapeutic options for gout arthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14967","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T20:49:04Z","timestamp":1577479744000},"page":"2042-2057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-6292","authenticated-orcid":false,"given":"Chengyu","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Acupuncture Research The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Acupuncture Research The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Science Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Acupuncture Research The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Acupuncture Research The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Acupuncture Research The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tai","sequence":"additional","affiliation":[{"name":"Academy of Chinese Medical Sciences Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-4548","authenticated-orcid":false,"given":"Boyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Acupuncture Research The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.17-1-54"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00261"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"S247","article-title":"The concise guide to pharmacology 2019\/20: Catalytic receptors","volume":"176","author":"Alexander S. 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