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Novel therapeutic strategies are required to protect the myocardium against the effects of acute ischaemia\u2013reperfusion injury (IRI). These include one or more brief cycles of non\u2010lethal ischaemia and reperfusion prior to the ischaemic event (ischaemic preconditioning [IPC]) or at the onset of reperfusion (ischaemic postconditioning [IPost]) either to the heart or to extracardiac organs (remote ischaemic conditioning [RIC]). Studies suggest that the diabetic heart is resistant to cardioprotective strategies, although clinical evidence is lacking. We overview the available animal models of diabetes, investigating acute myocardial IRI and cardioprotection, experiments investigating the effects of hyperglycaemia on susceptibility to acute myocardial IRI, the response of the diabetic heart to cardioprotective strategies e.g. IPC, IPost and RIC. Finally we highlight the effects of anti\u2010hyperglycaemic agents on susceptibility to acute myocardial IRI and cardioprotection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.23\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.23\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.14993","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T08:51:30Z","timestamp":1580115090000},"page":"5312-5335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Effect of hyperglycaemia and diabetes on acute myocardial ischaemia\u2013reperfusion injury and cardioprotection by ischaemic conditioning protocols"],"prefix":"10.1111","volume":"177","author":[{"given":"Claudia","family":"Penna","sequence":"first","affiliation":[{"name":"Department of Clinical and Biological Sciences University of 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