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Its clinical translation, however, is still an unmet need. This is mainly due to the disrupted cardioprotective signalling pathways in the presence of different cardiovascular risk factors, co\u2010morbidities and the medication being taken. Sensory neuropathy is one of the co\u2010morbidities that has been shown to interfere with cardioprotection. In the present review, we summarize the diverse aetiology of sensory neuropathies and the mechanisms by which these neuropathies may interfere with ischaemic heart disease and cardioprotective signalling. Finally, we suggest future therapeutic options targeting both ischaemic heart and sensory neuropathy simultaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.23\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.23\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15021","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T00:47:50Z","timestamp":1581727670000},"page":"5336-5356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-6232","authenticated-orcid":false,"given":"P\u00e9ter","family":"Bencsik","sequence":"first","affiliation":[{"name":"Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine University of Szeged  Szeged Hungary"},{"name":"Pharmahungary Group  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-3138","authenticated-orcid":false,"given":"Kamilla","family":"G\u00f6m\u00f6ri","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine University of Szeged  Szeged Hungary"},{"name":"Pharmahungary Group  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Szabados","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine University of Szeged  Szeged Hungary"},{"name":"Pharmahungary Group  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"S\u00e1ntha","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Helyes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Molecular Pharmacology Research Group, Centre for Neuroscience, J\u00e1nos Szent\u00e1gothai Research Centre University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Jancs\u00f3","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Ferdinandy","sequence":"additional","affiliation":[{"name":"Pharmahungary Group  Szeged Hungary"},{"name":"Department of Pharmacology and Pharmacotherapy Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3","family":"G\u00f6rbe","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine University of Szeged  Szeged Hungary"},{"name":"Pharmahungary Group  Szeged Hungary"},{"name":"Department of Pharmacology and Pharmacotherapy Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0210-4"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.14797\/mdcj-14-4-251","article-title":"Cardiac autonomic neuropathy in diabetes mellitus","volume":"14","author":"Agashe S.","year":"2018","journal-title":"Methodist DeBakey Cardiovascular Journal"},{"issue":"1","key":"e_1_2_13_4_1","first-page":"S142","article-title":"The Concise Guide to PHARMACOLOGY 2019\/20: Introduction and other protein targets","volume":"1","author":"Alexander S. 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