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Our previous studies demonstrated that TA<jats:sub>1<\/jats:sub> agonists attenuated cue\u2010 and drug\u2010induced cocaine\u2010seeking and increased the elasticity of the cocaine demand curve, in the short\u2010access cocaine self\u2010administration model. Compulsive use of cocaine, which is an essential criterion of cocaine use disorder, can be induced by extended access to cocaine self\u2010administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>To characterize the role of TA<jats:sub>1<\/jats:sub> in compulsive cocaine use, we evaluated the effects of activation of TA<jats:sub>1<\/jats:sub> on cocaine intake, cocaine binge and cue\u2010induced cocaine\u2010seeking using the extended\u2010access cocaine self\u2010administration model in adult male Sprague\u2013Dawley rats. We also investigated the role of TA<jats:sub>1<\/jats:sub> in stress\u2010triggered cocaine relapse by using the \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor antagonist yohimbine\u2010induced reinstatement of cocaine\u2010seeking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The selective TA<jats:sub>1<\/jats:sub> partial agonist RO5263397 attenuated cocaine intake and did not develop tolerance during the 10\u2010day extended\u2010access cocaine self\u2010administration. RO5263397 reduced a 12\u2010h binge intake of cocaine after forced abstinence. RO5263397 also decreased cue\u2010induced cocaine\u2010seeking after prolonged abstinence from extended\u2010access cocaine self\u2010administration. Furthermore, RO5263397 and the selective TA<jats:sub>1<\/jats:sub> full agonist RO5166017 reduced yohimbine\u2010induced reinstatement of cocaine\u2010seeking behaviour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>Activation of TA<jats:sub>1<\/jats:sub> attenuated extended\u2010access cocaine self\u2010administration and stress\u2010induced cocaine reinstatement. These results suggest that TA<jats:sub>1<\/jats:sub> agonists are promising pharmacological interventions to treat cocaine use disorder and relapse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15061","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T01:55:25Z","timestamp":1585965325000},"page":"3403-3414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["TA<sub>1<\/sub> agonists attenuate extended\u2010access cocaine self\u2010administration and yohimbine\u2010induced reinstatement of cocaine\u2010seeking"],"prefix":"10.1111","volume":"177","author":[{"given":"Jianfeng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology University at Buffalo  Buffalo New York 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