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We assess the scope for targeting key host and viral targets in the mid\u2010term, by first screening these targets against drugs already licensed, an agenda for drug repurposing, which should allow rapid translation to clinical trials. A simultaneous, multi\u2010pronged approach using conventional drug discovery methods aimed at discovering novel chemical and biological means of targeting a short list of host and viral entities which should extend the arsenal of anti\u2010SARS\u2010CoV\u20102 agents. This longer term strategy would provide a deeper pool of drug choices for future\u2010proofing against acquired drug resistance. Second, there will be further viral threats, which will inevitably evade existing vaccines. This will require a coherent therapeutic strategy which pharmacology and pharmacologists are best placed to provide.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on The Pharmacology of COVID\u201019. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.21\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.21\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15094","type":"journal-article","created":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T05:27:45Z","timestamp":1588397265000},"page":"4942-4966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["A rational roadmap for SARS\u2010CoV\u20102\/COVID\u201019 pharmacotherapeutic research and development: IUPHAR Review 29"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-497X","authenticated-orcid":false,"given":"Steve P.H.","family":"Alexander","sequence":"first","affiliation":[{"name":"Chair, Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC\u2010IUPHAR), School of Life Sciences University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-0260","authenticated-orcid":false,"given":"Jane F.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Curator, Guide to PHARMACOLOGY (GtoPdb), Deanery of Biomedical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2096-3117","authenticated-orcid":false,"given":"Anthony P.","family":"Davenport","sequence":"additional","affiliation":[{"name":"Executive Committee, NC\u2010IUPHAR University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6660-4032","authenticated-orcid":false,"given":"Jamie A.","family":"Davies","sequence":"additional","affiliation":[{"name":"Principal Investigator, Guide to PHARMACOLOGY (GtoPdb), Executive Committee, NC\u2010IUPHAR, Deanery of Biomedical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9855-7103","authenticated-orcid":false,"given":"Elena","family":"Faccenda","sequence":"additional","affiliation":[{"name":"Curator, Guide to PHARMACOLOGY (GtoPdb), Deanery of Biomedical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-8318","authenticated-orcid":false,"given":"Simon D.","family":"Harding","sequence":"additional","affiliation":[{"name":"Database Developer, Guide to PHARMACOLOGY (GtoPdb), Deanery of Biomedical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-2810","authenticated-orcid":false,"given":"Francesca","family":"Levi\u2010Schaffer","sequence":"additional","affiliation":[{"name":"First Vice\u2010President and Chair of Immunopharmacology Section, International Union of Basic and Clinical Pharmacology (IUPHAR) Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-7040","authenticated-orcid":false,"given":"Janet J.","family":"Maguire","sequence":"additional","affiliation":[{"name":"University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-845X","authenticated-orcid":false,"given":"Adam J.","family":"Pawson","sequence":"additional","affiliation":[{"name":"Senior Curator, Guide to PHARMACOLOGY (GtoPdb), Executive Committee, NC\u2010IUPHAR, Deanery of Biomedical Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9580-0446","authenticated-orcid":false,"given":"Christopher","family":"Southan","sequence":"additional","affiliation":[{"name":"Deanery of Biomedical Sciences University of Edinburgh  Edinburgh UK"},{"name":"TW2Informatics Ltd  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-8221","authenticated-orcid":false,"given":"Michael","family":"Spedding","sequence":"additional","affiliation":[{"name":"Secretary\u2010General, International Union of Basic and Clinical Pharmacology (IUPHAR) and Spedding Research Solutions SAS  Le Vesinet France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1686","article-title":"Catalytic cleavage of the androgen\u2010regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia","volume":"61","author":"Afar D. 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