{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:39:34Z","timestamp":1784173174331,"version":"3.55.0"},"reference-count":92,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["ID 101390"],"award-info":[{"award-number":["ID 101390"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["ID 20045"],"award-info":[{"award-number":["ID 20045"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Chemotherapy\u2010induced immune\u2010suppression is a common, but potential detrimental, adverse reaction in patients undergoing treatment for cancer and strategies with capacity to boost the immune cell populations are needed. Physical exercise training is a potent regulator of immune cell viability and function and may serve as a viable, non\u2010pharmacological prophylactic strategy in addition to the current pharmacological management by, for example, granulocyte\u2010colony stimulating factor (G\u2010CSF). Here, we review the mechanistic evidence linking exercise training to haematopoietic function and subsequent possible amelioration of chemotherapy\u2010related neutropenia. First, we briefly describe neutrophil regulation and management of neutropenia in cancer patients. Second, we summarize the effect of acute and chronic exercise training on neutrophils and their progenitors, and finally, we outline the current clinical evidence of exercise interventions in ongoing anti\u2010cancer treatment in regard to neutropenia incidence, treatment tolerance and related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on New avenues in cancer prevention and treatment (BJP 75th Anniversary). To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.12\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.12\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15141","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T12:49:50Z","timestamp":1590410990000},"page":"2925-2937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Exercise training as prophylactic strategy in the management of neutropenia during chemotherapy"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-3954","authenticated-orcid":false,"given":"Tim","family":"Schauer","sequence":"first","affiliation":[{"name":"Centre for Physical Activity Research, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille","family":"Hojman","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-0210","authenticated-orcid":false,"given":"Julie","family":"Gehl","sequence":"additional","affiliation":[{"name":"Center for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Clinical Oncology and Palliative Care Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-1505","authenticated-orcid":false,"given":"Jesper Frank","family":"Christensen","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.10.001"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14748"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14751"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.3.761.bloodjournal883761"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/724982"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8148742","article-title":"Neutrophil and monocyte bactericidal responses to 10 weeks of low\u2010volume high\u2010intensity interval or moderate\u2010intensity continuous training in sedentary adults","volume":"2017","author":"Bartlett D. B.","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"4","key":"e_1_2_12_8_1","first-page":"638","article-title":"Influence of endurance exercise on the risk of pneumonia and Fever in leukemia and lymphoma patients undergoing high dose chemotherapy. A pilot study","volume":"11","author":"Baumann F. T.","year":"2012","journal-title":"Journal of Sports Science & Medicine"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V68.1.162.162"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.07.011"},{"issue":"2","key":"e_1_2_12_11_1","first-page":"131","article-title":"Review: Drug\u2010induced neutropenia \u2010 pathophysiology, clinical features, and management","volume":"34","author":"Bhatt V.","year":"2004","journal-title":"Annals of Clinical Laboratory Science"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.02.005"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00376.2002"},{"issue":"35","key":"e_1_2_12_14_1","article-title":"A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults","volume":"1","author":"Brown W. M. C.","year":"2015","journal-title":"Sports Medicine \u2010 Open"},{"issue":"648","key":"e_1_2_12_15_1","article-title":"Debunking the myth of exercise\u2010induced immune suppression: Redefining the impact of exercise on immunological health across the lifespan","volume":"9","author":"Campbell J. P.","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V24.6.780.780"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49419-z"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181c4dac1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.8.2012.2012"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2024"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2008.0012"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107183250305"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024385"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00717.2012"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1782"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007063430107"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6611"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.2"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.9.3390"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2008.05.005"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2016.10.008"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e32828622d7"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001894"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00925.2015"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM194806032382301"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.043"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3245"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02950.x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.248"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.01890"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.04.013"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.015"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.27"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.050682"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002181"},{"issue":"15","key":"e_1_2_12_47_1","article-title":"Effect of an exercise training intervention with resistance bands on blood cell counts during chemotherapy for lung cancer: a pilot randomized controlled trial","volume":"3","author":"Karvinen K. H","year":"2014","journal-title":"SpringerPlus"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2007.00797.x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw325"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.08.006"},{"issue":"1","key":"e_1_2_12_52_1","first-page":"76","article-title":"Leucocytosis after violent Exercise","volume":"7","author":"Larrabee R. C.","year":"1902","journal-title":"The Journal of Medical Research"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1025675"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.10.2154.2154"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25332"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/379093"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0030-x"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2017.1358173"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198806060-00002"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0262"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00797.2012"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2018.09.009"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00863397"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00863401"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.03.002"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000177064.65927.98"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.1055"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-259028"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199417040-00005"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199504000-00011"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1440-2440(00)80047-X"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.3.579"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30099-8"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0034-9"},{"issue":"5","key":"e_1_2_12_76_1","first-page":"397","article-title":"Hematopoietic stem cell senescence and cancer therapy\u2010induced long\u2010term bone marrow injury","volume":"2","author":"Shao L.","year":"2013","journal-title":"Translational Cancer Research"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S208754"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1211591"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1509"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1080\/0361073X.2010.484785"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.12.123"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.05.006"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972833"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050044"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182408639"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705722"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206175"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.1081"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-015-0669-x"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.10.003"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0178"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e3180332d36"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2216"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbph.15141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.15141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T10:14:35Z","timestamp":1692958475000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.15141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,20]]},"references-count":92,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/bph.15141"],"URL":"https:\/\/doi.org\/10.1111\/bph.15141","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,20]]},"assertion":[{"value":"2020-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}