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SARS\u2010CoV\u20102 infects human cells using ACE2, the transmembrane protease serine 2 (TMPRSS2) and the SARS\u2010CoV\u20102 main protease (M<jats:sup>pro<\/jats:sup>). Once bound to ACE2 and the other two proteases in concert they allow the virus replication and spread throughout the body. Our attention has been focused on the role of ACE2 as its binding to by the virus increases bradykinin and its metabolites, which facilitate inflammation in the lung (causing cough and fever), coagulation and the complement system. These three systems are involved in angioedema, cardiovascular dysfunction and sepsis, pathologies which occur in COVID\u201019 patients. Thus, we propose that blocking the kallikrein\u2013kinin system with lanadelumab, approved for hereditary angioedema, will prevent facilitation of these 3 systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed issue on The Pharmacology of COVID\u201019. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.21\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.21\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15154","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T16:51:20Z","timestamp":1591289480000},"page":"4866-4872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A lesson from a saboteur: High\u2010MW kininogen impact in coronavirus\u2010induced disease 2019"],"prefix":"10.1111","volume":"177","author":[{"given":"Chiara","family":"Colarusso","sequence":"first","affiliation":[{"name":"Department of Pharmacy (DIFARMA) University of Salerno  Fisciano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Terlizzi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (DIFARMA) University of Salerno  Fisciano Italy"},{"name":"ImmunePharma S.r.l. 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