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Candidates for repurposing include drugs that target COVID\u201019 pathobiology, including agents that alter angiotensin signalling. Recent data indicate that key findings in COVID\u201019 patients include thrombosis and endotheliitis. Activation of proteinase\u2010activated receptor 1 (PAR1), in particular by the serine protease thrombin, is a critical element in platelet aggregation and coagulation. PAR1 activation also impacts on the actions of other cell types involved in COVID\u201019 pathobiology, including endothelial cells, fibroblasts and pulmonary alveolar epithelial cells. Vorapaxar is an approved inhibitor of PAR1, used for treatment of patients with myocardial infarction or peripheral arterial disease. We discuss evidence for a possible beneficial role for vorapaxar in the treatment of COVID\u201019 patients and other as\u2010yet non\u2010approved antagonists of PAR1 and proteinase\u2010activated receptor 4 (PAR4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed issue on The Pharmacology of COVID\u201019. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.21\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v177.21\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15194","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T11:59:05Z","timestamp":1594209545000},"page":"4971-4974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Proteinase\u2010activated receptor 1: A target for repurposing in the treatment of COVID\u201019?"],"prefix":"10.1111","volume":"177","author":[{"given":"Krishna","family":"Sriram","sequence":"first","affiliation":[{"name":"Department of Pharmacology University of California San Diego  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Insel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of California San Diego  La Jolla CA USA"},{"name":"Department of Medicine University of California San Diego  La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072529"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14748"},{"key":"e_1_2_4_5_1","unstructured":"American Society of Hematology. 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