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In this review, we will discuss currently existing literature regarding the involvement of the sensory system in ALS. Human studies have reported intradermic small fibre loss, sensory axonal predominant neuropathy, as well as somatosensory cortex hyperexcitability. In line with this, ALS animal studies have demonstrated the involvement of several sensory components. Specifically, they have highlighted the impairment of sensory\u2013motor networks as a potential mechanism for the disease. The elucidation of these \u201cnon\u2010motor\u201d systems involvement, which might also be part of the degeneration process, should prompt the scientific community to re\u2010consider ALS as a pure motor neuron disease, which may in turn result in more holistic research approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on Recent advances in ALS pathogenesis and therapeutics. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v178.6\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v178.6\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15202","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T17:50:03Z","timestamp":1594921803000},"page":"1257-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinical and preclinical evidence of somatosensory involvement in amyotrophic lateral sclerosis"],"prefix":"10.1111","volume":"178","author":[{"given":"Javier","family":"Riancho","sequence":"first","affiliation":[{"name":"Service of Neurology Hospital Sierrallana\u2013IDIVAL  Torrelavega Spain"},{"name":"Department of Medicine and Psychiatry University of Cantabria  Santander Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Neurodegenerativas, CIBERNED Instituto Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Paz\u2010Fajardo","sequence":"additional","affiliation":[{"name":"Service of Internal Medicine Hospital Sierrallana\u2013IDIVAL  Torrelavega Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"L\u00f3pez de Muna\u00edn","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Neurodegenerativas, CIBERNED Instituto Carlos III  Madrid Spain"},{"name":"Neurosciences Area Biodonostia Research Institute  San Sebasti\u00e1n Spain"},{"name":"Neurology Department Donostia University Hospital\u2013OSAKIDETZA  San Sebasti\u00e1n Spain"},{"name":"Neurosciences Department Basque Country University  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00314-R"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.203"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"S229","article-title":"The Concise Guide to PHARMACOLOGY 2019\/20: Nuclear hormone receptors","volume":"176","author":"Alexander S. 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