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Although often conflagrated by proponents of recreational use, the legislative rescheduling of cannabis\u2010derived compounds, such as cannabidiol (CBD), has been associated with the steady increase in the pursuit of use of medicinal cannabis. One key driver in this interest has been the scientific demonstration of efficacy and safety of CBD in randomised, placebo\u2010controlled clinical trials in children and young adults with difficult\u2010to\u2010treat epilepsies, which has encouraged increasing numbers of human trials of CBD for other indications and in other populations. The introduction of CBD as the medicine Epidiolex in the United States (in 2018) and as Epidyolex in the European Union (in 2019) as the first cannabis\u2010derived therapeutic for the treatment of seizures was underpinned by preclinical research performed at the University of Reading. 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