{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:01:30Z","timestamp":1793404890360,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>The cytokine activin C is mainly expressed in small\u2010diameter dorsal root ganglion (DRG) neurons and suppresses inflammatory pain. However, the effects of activin C in neuropathic pain remain elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Male rats and wild\u2010type and TRPV1 knockout mice with peripheral nerve injury \u2010 sciatic nerve axotomy and spinal nerve ligation in rats; chronic constriction injury (CCI) in mice \u2013 provided models of chronic neuropathic pain. Ipsilateral lumbar (L)4\u20135 DRGs were assayed for activin C expression. Chronic neuropathic pain animals were treated with intrathecal or locally pre\u2010administered activin C or the vehicle. Nociceptive behaviours and pain\u2010related markers in L4\u20135 DRGs and spinal cord were evaluated. TRPV1 channel modulation by activin C was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Following peripheral nerve injury, expression of activin \u03b2C subunit mRNA and activin C protein was markedly up\u2010regulated in L4\u20135 DRGs of animals\n                      <jats:bold>with axotomy, SNL or CCI<\/jats:bold>\n                      . [Correction added on 26 November 2020, after first online publication: The preceding sentence has been corrected in this current version.] Intrathecal activin C dose\u2010dependently inhibited neuropathic pain in spinal nerve ligated rats. Local pre\u2010administration of activin C decreased neuropathic pain, macrophage infiltration into ipsilateral L4\u20135 DRGs and microglial reaction in L4\u20135 spinal cords of mice with CCI. In rat DRG neurons, activin C enhanced capsaicin\u2010induced TRPV1 currents. Pre\u2010treatment with activin C reduced capsaicin\u2010evoked acute hyperalgesia and normalized capsaicin\u2010evoked persistent hypothermia in mice. Finally, the analgesic effect of activin C was abolished in TRPV1 knockout mice with CCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>Activin C inhibits neuropathic pain by modulating TRPV1 channels, revealing potential analgesic applications in chronic neuropathic pain therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15284","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T13:35:13Z","timestamp":1603460113000},"page":"5642-5657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 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