{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:40:39Z","timestamp":1780461639010,"version":"3.54.1"},"reference-count":68,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR 905\/12\u20101"],"award-info":[{"award-number":["PR 905\/12\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1192\/ B6"],"award-info":[{"award-number":["SFB 1192\/ B6"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SK 46\/4\u20101"],"award-info":[{"award-number":["SK 46\/4\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PFZ SFB1192"],"award-info":[{"award-number":["PFZ SFB1192"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010281","name":"Kidneeds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>Factor H\u2010related protein 1 (FHR\u20101) is a member of the factor H protein family, which is involved in regulating innate immune complement reactions. Genetic modification of the encoding gene, <jats:italic>CFHR1<\/jats:italic> on human chromosome 1, is involved in diseases such as age\u2010related macular degeneration, C3 glomerulopathy and atypical haemolytic uraemic syndrome, indicating an important role for FHR\u20101 in human health. Recent research data demonstrate that FHR\u20101 levels increase in IgA nephropathy and anti\u2010neutrophilic cytoplasmic autoantibodies (ANCA) vasculitis and that FHR\u20101 induces strong inflammation in monocytes on necrotic\u2010type surfaces, suggesting a complement\u2010independent role. These new results increase our knowledge about the role of this complement protein in pathology and provide a new therapeutic target, particularly in the context of inflammatory diseases induced by necrosis. This review summarizes current knowledge about FHR\u20101 and discusses its role in complement reactions and inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Linked Articles<\/jats:title><jats:p>This article is part of a themed issue on Canonical and non\u2010canonical functions of the complement system in health and disease. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v178.14\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v178.14\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15290","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T19:23:56Z","timestamp":1603308236000},"page":"2823-2831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Factor H\u2010related protein 1: a complement regulatory protein and guardian of necrotic\u2010type surfaces"],"prefix":"10.1111","volume":"178","author":[{"given":"Christine","family":"Skerka","sequence":"first","affiliation":[{"name":"Department of Infection Biology Leibniz Institute for Natural Product Research and Infection Biology, Hans\u2010Kn\u00f6ll\u2010Institute  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Pradel","sequence":"additional","affiliation":[{"name":"Division of Cellular and Applied Infection Biology RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke D.","family":"Halder","sequence":"additional","affiliation":[{"name":"Department of Infection Biology Leibniz Institute for Natural Product Research and Infection Biology, Hans\u2010Kn\u00f6ll\u2010Institute  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Zipfel","sequence":"additional","affiliation":[{"name":"Department of Infection Biology Leibniz Institute for Natural Product Research and Infection Biology, Hans\u2010Kn\u00f6ll\u2010Institute  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svante L.H.","family":"Zipfel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Heart Center, University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Strau\u00df","sequence":"additional","affiliation":[{"name":"Experimental Ophthalmology Charit\u00e9 University Medicine, Campus Virchow Clinic  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-223834"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14748"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1913970117"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903678"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu317"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2019.102349"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-019-00619-2"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.63"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015020212"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23297"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101341"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050534"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.02.011"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.63.6.1256"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq399"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.787"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219260110"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00260-13"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890601097030"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3858"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009647"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166200"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-205641"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-006-0153-y"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060352"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10766-0"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484257"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2018.11.005"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00571"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-109876"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.12.018"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788216"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002765"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00385"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01123"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(00)00024-9"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.03.043"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12477"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.06.028"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017070738"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032187"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.195"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13925"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.30.18054"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.1.198"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.03.011"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800662"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3975"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600135"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.06.001"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99058-7"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.11.021"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200600287"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106134"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.05.025"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.09.001"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.03.041"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68280"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01727"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201600237"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002079"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012419-032847"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030041"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.11.015"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.05.222"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2620"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.03.012"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019050515"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.15290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T05:53:40Z","timestamp":1693288420000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.15290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,23]]},"references-count":68,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/bph.15290"],"URL":"https:\/\/doi.org\/10.1111\/bph.15290","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,23]]},"assertion":[{"value":"2020-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}