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However, both the pathogenesis and effective therapies for retinal photodamage are still unclear and debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>The anti\u2010inflammatory effects of thrombospondin\u20101 on blue light\u2010induced inflammation in ARPE\u201019 cells and in retinal inflammation were evaluated. Furthermore, the anti\u2010angiogenic effects of thrombospondin\u20101 on human microvascular endothelial cells (hMEC\u20101 cells) and a laser\u2010induced choroidal neovascularisation (CNV) mouse model were evaluated. in vitro experiments, including western blotting, immunocytochemistry, migration assays and tube formation assays, as well as in vivo experiments, including immunofluorescence, visual electrophysiology, spectral\u2010domain optical coherence tomography, and fluorescein angiography, were employed to evaluate the anti\u2010inflammatory and anti\u2010angiogenic effects of thrombospondin\u20101.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Specific effects of blue light\u2010induced retinal inflammation and pathological angiogenesis were reflected by up\u2010regulation of pro\u2010inflammatory factors and activation of angiogenic responses, predominantly regulated by the NF\u2010\u03baB and VEGFR2 pathways respectively. During the blue light\u2010induced pathological progress, THBS\u20101 derived from retinal pigment epithelium down\u2010regulated proteomics and biological assays. Thrombospondin\u20101 treatment also suppressed inflammatory infiltration and neovascular leakage. The protective effect of Thrombospondin\u20101 was additionally demonstrated by a substantial rescue of visual function. Mechanistically, thrombospondin\u20101 reversed blue light\u2010induced retinal inflammation and angiogenesis by blocking the activated NF\u2010\u03baB and VEGFR2 pathways, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>Thrombospondin\u20101, with dual anti\u2010inflammatory and anti\u2010neovascularisation properties, is a promising agent for protection against blue light\u2010induced retinal damage and retinal degenerative disorders which are pathologically associated with inflammatory and angiogenic progress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue on Inflammation, Repair and Ageing. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.9\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.9\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15303","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T15:35:00Z","timestamp":1604072100000},"page":"1938-1961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Protection against light\u2010induced retinal degeneration via dual anti\u2010inflammatory and anti\u2010angiogenic functions of thrombospondin\u20101"],"prefix":"10.1111","volume":"179","author":[{"given":"Yahan","family":"Ju","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital Shanghai 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