{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:12:13Z","timestamp":1792084333604,"version":"4.4.0"},"reference-count":114,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32473B_156525"],"award-info":[{"award-number":["32473B_156525"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_192738"],"award-info":[{"award-number":["310030_192738"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["323630\u2010183987"],"award-info":[{"award-number":["323630\u2010183987"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Immune cell trafficking is an important mechanism for the pathogenesis of inflammatory bowel disease (IBD). The oxysterol receptor GPR183 and its ligands, dihydroxylated oxysterols, can mediate positioning of immune cells including innate lymphoid cells. <jats:italic>GPR183<\/jats:italic> has been mapped to an IBD risk locus, however another gene, <jats:italic>Ubac2<\/jats:italic> is encoded on the reverse strand and associated with Beh\u00e7et's disease, therefore the role of <jats:italic>GPR183<\/jats:italic> as a genetic risk factor requires validation. <jats:italic>GPR183<\/jats:italic> and production of its oxysterol ligands are up\u2010regulated in human IBD and murine colitis. <jats:italic>Gpr183<\/jats:italic> inactivation reduced severity of colitis in group 3 innate lymphoid cells\u2010dependent colitis and in IL\u201010 colitis but not in dextran sodium sulphate colitis. Irrespectively, <jats:italic>Gpr183<\/jats:italic> knockout strongly reduced accumulation of intestinal lymphoid tissue in health and all colitis models. In conclusion, genetic, translational and experimental studies implicate GPR183 in IBD pathogenesis and GPR183\u2010dependent cell migration might be a therapeutic drug target for IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on Oxysterols, Lifelong Health and Therapeutics. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v178.16\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v178.16\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15311","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T13:53:42Z","timestamp":1604498022000},"page":"3140-3156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The oxysterol receptor GPR183 in inflammatory bowel diseases"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-5175","authenticated-orcid":false,"given":"Benjamin","family":"Misselwitz","sequence":"first","affiliation":[{"name":"Gastroenterology University Hospital of Visceral Surgery and Medicine, Inselspital Bern and Bern University  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Wyss","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Raselli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuk","family":"Cerovic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas W.","family":"Sailer","sequence":"additional","affiliation":[{"name":"Disease Area X Novartis Institutes for BioMedical Research  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-7536","authenticated-orcid":false,"given":"Niklas","family":"Krupka","sequence":"additional","affiliation":[{"name":"Gastroenterology University Hospital of Visceral Surgery and Medicine, Inselspital Bern and Bern University  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Service of Neurology, University of Lausanne  Lausanne Switzerland"},{"name":"Department of Clinical Neurosciences University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-3129","authenticated-orcid":false,"given":"Caroline","family":"Pot","sequence":"additional","affiliation":[{"name":"Service of Neurology, University of Lausanne  Lausanne Switzerland"},{"name":"Department of Clinical Neurosciences University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Pabst","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0701-5"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"S21","article-title":"The Concise Guide to PHARMACOLOGY 2019\/20: G protein\u2010coupled receptors","volume":"176","author":"Alexander S. P. H.","year":"2019","journal-title":"British Journal of Pharmacology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104892"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.90"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909142106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.4.2209-2220.1993"},{"key":"e_1_2_11_9_1","first-page":"38","article-title":"Interfering with leukocyte trafficking in Crohn's disease","author":"Biswas S.","year":"2019","journal-title":"Best Practice & Research. Clinical Gastroenterology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.004"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073274817729901"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07450"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.120.000105"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00342"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy083"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000125"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau0812"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.099"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.006"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-1138-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3760"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2016.34"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M900107-JLR200"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021761"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184522"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.010"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.86"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096472"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.020"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215734"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13398"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2695"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.02.001"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.717"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.06.016"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0813-876e"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4019355"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.02.019"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy157"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10280"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3180"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3789"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.120.264960"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.03.013"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.31"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.22"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101262"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.06.002"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.045"},{"key":"e_1_2_11_51_1","first-page":"147","article-title":"Designing biologic selectivity for inflammatory bowel disease\u2014Role of vedolizumab","volume":"9","author":"Krupka N.","year":"2015","journal-title":"Drug Design, Development and Therapy."},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.012"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-7580-4-5"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17947"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10226"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.005"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100052"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16060"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.11.5475"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12743"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aal5237"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2009.113"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303424"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.549"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301272"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00308"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.009"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694615"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646370"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213738110"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2089"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6824"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00861"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00676"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0610318"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10066"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08226"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy269"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.03.007"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.01.069"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090257"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M093229"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz039"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254790"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043335"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215739"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513248"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30604"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309333"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110156109"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222551"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322807111"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64503-8"},{"key":"e_1_2_11_94_1","article-title":"Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases","author":"Stepanovska B.","year":"2019","journal-title":"Pharmacological Research"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04605.x"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3786"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104234"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701885507"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx145"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.014"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.12.004"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-017-0162-4"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2832"},{"issue":"2","key":"e_1_2_11_104_1","first-page":"72","article-title":"Influence of environmental factors in the development and outcomes of inflammatory bowel disease","volume":"15","author":"Vedamurthy A.","year":"2019","journal-title":"Gastroenterology & Hepatology"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801141"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.017"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0454"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12855"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026617666170713165519"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0140-x"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00877-3"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00757"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.015"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200401000-00008"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1720"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.15311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:36:29Z","timestamp":1693344989000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.15311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,12]]},"references-count":114,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/bph.15311"],"URL":"https:\/\/doi.org\/10.1111\/bph.15311","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,12]]},"assertion":[{"value":"2020-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}