{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:48:27Z","timestamp":1790952507486,"version":"4.1.0"},"reference-count":150,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/08264\u20108"],"award-info":[{"award-number":["2017\/08264\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/25053\u20103"],"award-info":[{"award-number":["2018\/25053\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/02766\u20107"],"award-info":[{"award-number":["2019\/02766\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/05040\u20104"],"award-info":[{"award-number":["2020\/05040\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/02684\u20108"],"award-info":[{"award-number":["2017\/02684\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["427413\/2018\u20104"],"award-info":[{"award-number":["427413\/2018\u20104"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Lipids govern vital cellular processes and drive physiological changes in response to different pathological or environmental cues. Lipid species can be roughly divided into structural and signalling lipids. The former is essential for membrane composition, while the latter are usually oxidized lipids. These mediators provide beneficial effects against cardiometabolic diseases (CMDs), including fatty\u2010liver diseases, atherosclerosis, thrombosis, obesity, and Type 2 diabetes. For instance, several oxylipins were recently found to improve glucose homeostasis, increase insulin secretion, and inhibit platelet aggregation, while specialized pro\u2010resolving mediators (SPMs) are able to ameliorate CMD by shaping the immune system. These lipids act mainly by stimulating GPCRs. In this review, we provide an updated and comprehensive overview of the current state of the literature on signalling lipids in the context of CMD. We also highlight the network encompassing the lipid\u2010modifying enzymes and the lipid\u2010binding GPCRs, as well as their interactions in health and disease.<\/jats:p>","DOI":"10.1111\/bph.15321","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T04:02:57Z","timestamp":1604980977000},"page":"531-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploiting oxidized lipids and the lipid\u2010binding GPCRs against cardiometabolic diseases"],"prefix":"10.1111","volume":"178","author":[{"given":"Raphael C.","family":"Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Obesity and Comorbidities Research Center  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7503-6062","authenticated-orcid":false,"given":"Tiago T.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"},{"name":"Center for Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"},{"name":"Department of Pharmacology, Faculty of Medical Sciences State University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-3705","authenticated-orcid":false,"given":"Luiz O.","family":"Leiria","sequence":"additional","affiliation":[{"name":"Obesity and Comorbidities Research Center  Campinas Brazil"},{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"},{"name":"Center for Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14748"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14750"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14751"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14752"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14747"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14753"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042031"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00699.2003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0169-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45062-w"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.12.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902055R"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.11.004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-1317"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aar3721"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700082R"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.023"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.06.012"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"1","article-title":"Structural basis of ligand binding modes at the human formyl peptide receptor 2","volume":"11","author":"Chen T.","year":"2020","journal-title":"Nature Communications"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.10.023"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150225"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601650"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11042"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129448"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0489-8"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201272"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.21.9475"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308253110"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328342bb1a"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01940"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14336"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-020-00221-0"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102362"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.01.022"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903526"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0040"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132011"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2002"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.253"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.04.045"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.01.016"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12859"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410851111"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.468603"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153751"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0370-1"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14587"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.1663"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002034"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070703"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001316"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124219"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-178657"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402166"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.33"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1063"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M026385"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.340612"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425688"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.03.013"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000885"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.246686"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.150"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.116.013177"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2015.05.007"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.10.141"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0111"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402534"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.01.028"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907342107"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.10.002"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa183"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032801"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.09.018"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.07.001"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/89759"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14041"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3HI0517-206RR"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.03.092"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15951-z"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aar8320"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1519644112"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4297"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.03.012"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-014-0792-7"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600859R"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.004648"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000438"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-44"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.10.024"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00596"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0828"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.15.4.534"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.041"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.044131"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-015-1976-x"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04474-2"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00370.2014"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000830R"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.02.017"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.06.082"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.209213"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm786"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2470"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13707"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu224"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.01.034"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14232"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0198-8"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.01.038"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.90"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)90629-Y"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.22.2677"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00150a021"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.21.7393"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902126R"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(10)70306-6"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501701"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2013.12.008"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1848"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15055-9"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2639"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13185-7"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.3181\/0711-MR-311"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4054-0"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.10.006"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100196"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.020"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.2.395"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2009.09.004"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306256"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.676890"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.210"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100225"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502522"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017006155"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02539-4"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13215"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1186034"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309492"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0054"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3549"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2018.73155"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.308050"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/42506"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9010011"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14728-9"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.15321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T17:40:31Z","timestamp":1693330831000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.15321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,23]]},"references-count":150,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/bph.15321"],"URL":"https:\/\/doi.org\/10.1111\/bph.15321","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,23]]},"assertion":[{"value":"2020-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}