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Rutin is a metabolic regulator with a poor solubility. Using soluble sodium rutin we investigating the effect and mechanisms of rutin in ageing process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Wild type male mice were treated with or without sodium rutin ( 0.2\u00a0mg\u00b7ml<jats:sup>\u22121<\/jats:sup> in drinking water from 8\u2010month\u2010old until end of life. Kaplan\u2013Meier survival curve was used for lifespan assay, ageing\u2010related histopathology analysis and metabolic analysis were performed to determine the effects of chronic sodium rutin on the longevity. Serological test, liver tissue metabolomics and transcriptomics were used for liver function assay. SiRNA knockdown Angptl8 and autophagy flux assay in HepG2 cell lines explored the mechanism through which sodium rutin might impact the function of hepatocyte.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Sodium rutin treatment extends the lifespan of mice by 10%. Sodium rutin supplementation alleviates ageing\u2010related pathological changes and promotes behaviour performance in ageing mice. Sodium rutin supplementation altered the whole\u2010body metabolism in mice, which exhibited increased energy expenditure and lower respiratory quotient. Transcriptomics analysis showed that Sodium rutin affected the expression of metabolic genes. Metabolomics analysis showed that Sodium rutin reduced liver steatosis through increased lipid \u03b2\u2010oxidation. Sodium rutin treatment increased the autophagy level both in vivo and in vitro. The inhibition of autophagy partially abolished the sodium rutin\u2010mediated effect on lipolysis in HepG2 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>Sodium rutin treatment extends the lifespan and health span of mice with beneficial effects on metabolism, which were achieved by enhancing the autophagy activity in hepatocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on Inflammation, Repair and Ageing. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.9\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.9\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15410","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T13:41:43Z","timestamp":1612791703000},"page":"1825-1838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Sodium rutin extends lifespan and health span in mice including positive impacts on liver health"],"prefix":"10.1111","volume":"179","author":[{"given":"Shuoshuo","family":"Li","sequence":"first","affiliation":[{"name":"The Brain Science Center Beijing Institute of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyuan","family":"Pan","sequence":"additional","affiliation":[{"name":"The Brain Science Center Beijing Institute of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Brain Science Center Beijing Institute of Basic Medical Sciences  Beijing China"},{"name":"Center on Translational Neuroscience, College of Life &amp; Environmental Science Minzu University of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Center for Noncoding RNA Medicine, School of Basic Medical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-5638","authenticated-orcid":false,"given":"Jianxin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Brain Science Center Beijing Institute of Basic Medical Sciences  Beijing China"},{"name":"Beijing Institute for Brain Disorders Capital Medical University  Beijing China"},{"name":"Center on Translational Neuroscience, College of Life &amp; Environmental Science Minzu University of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","first-page":"S1","article-title":"The Concise Guide to PHARMACOLOGY 2019\/20: Introduction and other protein targets","volume":"176","author":"Alexander S. 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