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Patients with neovascular AMD (nAMD) are treated with frequent intraocular injections of anti\u2010vascular endothelial growth factor (VEGF) therapies, which are not only unpopular with patients but carry risks of sight\u2010threatening complications. A minority of patients are unresponsive with no alternative treatment available, and some patients who respond initially eventually develop a tolerance to treatment. New therapeutics with improved delivery methods and sustainability of clinical effects are required, in particular for non\u2010neovascular AMD (90% of cases and no current approved treatments). There are age\u2010related and disease\u2010related changes that occur which can affect ocular drug delivery. Here, we review the latest emerging therapies for AMD, their delivery routes and implications for translating to clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on Inflammation, Repair and Ageing. 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