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However, there is an increasing desire for alternative model systems that provide excellent scientific value while replacing or reducing the use of mammals. Here, we review the use of zebrafish, <jats:styled-content style=\"fixed-case\"><jats:italic>Danio rerio<\/jats:italic><\/jats:styled-content>, to study cardiovascular development and disease. The anatomy and physiology of zebrafish and mammalian cardiovascular systems are compared, and we describe the use of zebrafish models in studying the mechanisms of cardiac (e.g. congenital heart defects, cardiomyopathy, conduction disorders and regeneration) and vascular (endothelial dysfunction and atherosclerosis, lipid metabolism, vascular ageing, neurovascular physiology and stroke) pathologies. We also review the use of zebrafish for studying pharmacological responses to cardiovascular drugs and describe several features of zebrafish that make them a compelling model for in vivo screening of compounds for the treatment cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.5\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.5\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15473","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T11:44:24Z","timestamp":1617191064000},"page":"900-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":153,"title":["Zebrafish as a tractable model of human cardiovascular disease"],"prefix":"10.1111","volume":"179","author":[{"given":"George","family":"Bowley","sequence":"first","affiliation":[{"name":"Department of Infection, Immunity and Cardiovascular Disease University of Sheffield  Sheffield UK"},{"name":"Bateson Centre University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-6140","authenticated-orcid":false,"given":"Elizabeth","family":"Kugler","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Cardiovascular Disease University of Sheffield  Sheffield UK"},{"name":"Bateson Centre University of Sheffield  Sheffield UK"},{"name":"Institute of Ophthalmology, Faculty of Brain Sciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"School of Life Sciences University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Lawrie","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Cardiovascular Disease University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freek","family":"van Eeden","sequence":"additional","affiliation":[{"name":"Bateson Centre University of Sheffield  Sheffield UK"},{"name":"Department of Biomedical Science University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J. 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