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As <jats:italic>in vitro<\/jats:italic> cell\u2010based models do not depict the complexity of the human heart, animal models are used to obtain insights that can be translated to human diseases. Mice are the most commonly used animals in cardiac research. However, differences in electrophysiological and mechanical cardiac function and a different composition of electrical and contractile proteins limit the transferability of the knowledge gained. Moreover, the small heart size and fast heart rate are major disadvantages. In contrast to rodents, electrophysiological, mechanical and structural cardiac characteristics of rabbits resemble the human heart more closely, making them particularly suitable as an animal model for cardiac disease research. In this review, various methodological approaches for the generation of transgenic rabbits for cardiac disease research, such as pronuclear microinjection, the sleeping beauty transposon system and novel genome\u2010editing methods (ZFN and CRISPR\/Cas9)will be discussed. In the second section, we will introduce the different currently available transgenic rabbit models for monogenic cardiac diseases (such as long QT syndrome, short\u2010QT syndrome and hypertrophic cardiomyopathy) in detail, especially in regard to their utility to increase the understanding of pathophysiological disease mechanisms and novel treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.5\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.5\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15484","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T13:40:10Z","timestamp":1617716410000},"page":"938-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Transgenic rabbit models for cardiac disease research"],"prefix":"10.1111","volume":"179","author":[{"given":"Tibor","family":"Hornyik","sequence":"first","affiliation":[{"name":"Translational Cardiology, Department of Cardiology, Inselspital, Bern University Hospital, and Institute of Physiology University of Bern  Bern Switzerland"},{"name":"Department of Cardiology and Angiology I, University Heart Center, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Rieder","sequence":"additional","affiliation":[{"name":"Translational Cardiology, Department of Cardiology, Inselspital, Bern University Hospital, and Institute of Physiology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Castiglione","sequence":"additional","affiliation":[{"name":"Translational Cardiology, Department of Cardiology, Inselspital, Bern University Hospital, and Institute of Physiology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Major","sequence":"additional","affiliation":[{"name":"Institute for Genetics and Biotechnology Hungarian University of Agriculture and Life Sciences  G\u00f6d\u00f6ll\u0151 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Baczko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, University Heart Center, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Department of Cardiology and Medical Intensive Care St. Josefskrankenhaus  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Koren","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja E.","family":"Odening","sequence":"additional","affiliation":[{"name":"Translational Cardiology, Department of Cardiology, Inselspital, Bern University Hospital, and Institute of Physiology University of Bern  Bern Switzerland"},{"name":"Department of Cardiology and Angiology I, University Heart Center, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","first-page":"S1","article-title":"The concise guide to pharmacology 2019\/20: Introduction and other protein targets","volume":"176","author":"Alexander S. 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