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Exaggerated 50\u2010kHz USV emission evoked by d\u2010amphetamine is modulated by dopamine, noradrenaline and 5\u2010hydroxytyrptamine receptor ligands and inhibited by the mood stabilizer lithium, the gold standard anti\u2010manic drug for treating bipolar disorder. This indicates that exaggerated 50\u2010kHz USV emission can serve as a reliable and valid measure for assessing mania\u2010like elevated mood in rats with sufficient translational power for gaining a better understanding of relevant pathophysiological mechanisms and the identification of new therapeutic targets. The improved capacity to study the effects of anti\u2010manic pharmacological interventions on a broader range of behaviours by including exaggerated 50\u2010kHz USV emission as preclinical outcome measure complementary to locomotor hyperactivity will refine rodent models for mania.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on New discoveries and perspectives in mental and pain disorders. 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