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Glucagon\u2010like peptide 1 (GLP\u20101) is a hormone that has growth factor\u2010like and neuroprotective properties. Several clinical trials have been conducted, testing GLP\u20101 receptor agonists in patients with Alzheimer's disease, Parkinson's disease or diabetes\u2010induced memory impairments. The trials showed clear improvements in Alzheimer's disease, Parkinson's disease and diabetic patients. Glucose\u2010dependent insulinotropic polypeptide\/gastric inhibitory peptide (GIP) is the \u2018sister\u2019 incretin hormone of GLP\u20101. GIP analogues have shown neuroprotective effects in animal models of disease and can improve on the effects of GLP\u20101. Novel dual GLP\u20101\/GIP receptor agonists have been developed that can enter the brain at an enhanced rate. The improved neuroprotective effects of these drugs suggest that they are superior to single GLP\u20101 receptor agonists and could provide disease\u2010modifying care for Alzheimer's disease and Parkinson's disease patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). 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