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Treatment\u2010resistant depression (TRD) is a major challenge for the psychopharmacology of mood disorders. Only in the past decade have novel treatments, including deep brain stimulation (DBS) and ketamine, been discovered that provide rapid and sometimes prolonged relief to a high proportion of TRD sufferers. 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To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.17\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.17\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15596","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T23:18:36Z","timestamp":1623712716000},"page":"4181-4200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Perspectives for therapy of treatment\u2010resistant depression"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1282-3939","authenticated-orcid":false,"given":"Mariusz","family":"Papp","sequence":"first","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences  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