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Preclinical studies have identified oxytocin as a promising pharmacotherapy with anticraving properties for addictive behaviours. Here, we provide the first systematic review of 17 human studies (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009722; 30% female) investigating the efficacy of intranasal oxytocin to reduce craving or consumption in addictive behaviours. We identify intranasal oxytocin as a method that warrants further investigation regarding its capacity to decrease cue\u2010induced, acute stress\u2010induced or withdrawal\u2010related craving and relapse related to alcohol, cannabis, opioids, cocaine or nicotine, including a potential role as\n                    <jats:italic>ad hoc<\/jats:italic>\n                    medication following exposure to drug\u2010related cues. Future studies should investigate the role of factors such as treatment regimens and sample characteristics, including the role of the amygdala, which we propose as a distinct mechanism mediating oxytocin's anticraving properties.\n                  <\/jats:p>","DOI":"10.1111\/bph.15617","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T23:48:51Z","timestamp":1625701731000},"page":"4316-4334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Can intranasal oxytocin reduce craving in automated addictive behaviours? 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