{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:43:42Z","timestamp":1772102622647,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>The present work provides arguments for the involvement of anti\u2010vector immunity and of SARS\u2010CoV\u20102 variants on the efficacy of ChAdOx1 nCoV\u201019 vaccine. First, it is suggested that anti\u2010vector immunity takes place as homologous vaccination with ChAdOx1 nCoV\u201019 vaccine is applied and interferes with vaccine efficacy when the interval between prime and booster doses is less than 3\u2009months. Second, longitudinal studies suggest that ChAdOx1 nCoV\u201019 vaccine provides suboptimal efficacy against SARS\u2010CoV\u20102 Alpha variant, which appears to have an increased transmissibility among vaccinated people. At the moment, ChAdOx1 nCoV\u201019 vaccine is able to reduce the severity of symptoms and transmissibility. However, if the vaccinated individuals do not maintain physical preventive measures, they could turn into potential spreaders, thus suggesting that mass vaccination will not quickly solve the pandemic. Possible consequences of SARS\u2010CoV\u20102 evolution and of repeated anti\u2010SARS\u2010CoV\u20102 vaccinations are discussed and adoption of an influenza\u2010like vaccination strategy is suggested.<\/jats:p>","DOI":"10.1111\/bph.15620","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T13:09:43Z","timestamp":1627736983000},"page":"218-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypothesis: Possible influence of antivector immunity and SARS\u2010CoV\u20102 variants on efficacy of ChAdOx1 nCoV\u201019 vaccine"],"prefix":"10.1111","volume":"179","author":[{"given":"Loris","family":"Zamai","sequence":"first","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino Carlo Bo  Urbino Italy"},{"name":"Gran Sasso National Laboratory (LNGS) National Institute for Nuclear Physics (INFN)  L'Aquila Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco B. L.","family":"Rocchi","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino Carlo Bo  Urbino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14752"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14747"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n579"},{"key":"e_1_2_10_5_1","unstructured":"Chambers J.(2021).Chile sees Covid surge despite vaccination success. Retrieved fromhttps:\/\/www.bbc.com\/news\/world-latin-america-56731801"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01294-w"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg3055"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03426-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00628-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31604-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11020122"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.9976"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00292-w"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.26.1.2002106"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102214"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32466-1"},{"key":"e_1_2_10_17_1","unstructured":"Roxby P.(2021).Are Covid patients getting younger?Retrieved fromhttps:\/\/www.bbc.com\/news\/health-55586994"},{"key":"e_1_2_10_18_1","unstructured":"Schraer R.(2021).Covid Indian variant: Where is it how does it spread and is it more infectious?Retrieved fromhttps:\/\/www.bbc.com\/news\/health-57157496"},{"key":"e_1_2_10_19_1","first-page":"S1931","article-title":">SARS\u2010CoV\u20102 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines","volume":"5","author":"Shen X.","year":"2021","journal-title":"Cell Host & Microbe"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.037"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba8399"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2608-y"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03470-x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00432-3"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32661-1"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03398-2"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01285-x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n359"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00802-x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071704"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030506"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.037"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.15620","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:17:56Z","timestamp":1692976676000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.15620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,31]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/bph.15620"],"URL":"https:\/\/doi.org\/10.1111\/bph.15620","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,31]]},"assertion":[{"value":"2021-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}