{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:47:07Z","timestamp":1777520827139,"version":"3.51.4"},"reference-count":85,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"am","delay-in-days":323,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR14G2"],"award-info":[{"award-number":["JPMJCR14G2"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15H04999"],"award-info":[{"award-number":["JP15H04999"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H04669"],"award-info":[{"award-number":["JP16H04669"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H06280"],"award-info":[{"award-number":["JP16H06280"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K08635"],"award-info":[{"award-number":["JP16K08635"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K18390"],"award-info":[{"award-number":["JP16K18390"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K18977"],"award-info":[{"award-number":["JP16K18977"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H01854"],"award-info":[{"award-number":["JP17H01854"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K11478"],"award-info":[{"award-number":["JP17K11478"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K06481"],"award-info":[{"award-number":["JP18K06481"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K19625"],"award-info":[{"award-number":["JP18K19625"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H04746"],"award-info":[{"award-number":["JP19H04746"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H05060"],"award-info":[{"award-number":["JP20H05060"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H05902"],"award-info":[{"award-number":["JP20H05902"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K07751"],"award-info":[{"award-number":["JP20K07751"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K09786"],"award-info":[{"award-number":["JP20K09786"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K20942"],"award-info":[{"award-number":["JP20K20942"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K21506"],"award-info":[{"award-number":["JP20K21506"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20KK0366"],"award-info":[{"award-number":["JP20KK0366"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["Cooperative Research Program of \u201cNetwork Joint Research Center for Materials and Devices\u201d"],"award-info":[{"award-number":["Cooperative Research Program of \u201cNetwork Joint Research Center for Materials and Devices\u201d"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20gm1310008s0101"],"award-info":[{"award-number":["20gm1310008s0101"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Glaucoma, the leading cause of blindness, damages the retinal ganglion cells. Elevated intraocular pressure (IOP) is a high\u2010risk factor for glaucoma, so topical hypotensive drugs are usually used for treatment. Because not all patients do not respond adequately to current treatments, there is a need to identify a new molecular target to reduce IOP. Here, we have assessed the role of P2Y1 receptors in mediating elevated IOP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>P2Y<jats:sub>1<\/jats:sub> receptor agonist was instilled into the eyes of mice, and the IOP changes were measured by a rebound\u2010type tonometer. Expression of P2Y<jats:sub>1<\/jats:sub> receptors was estimated by immunohistochemistry. Ocular function was measured by a multifocal electroretinogram.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A single dose of the P2Y<jats:sub>1<\/jats:sub> receptor agonist transiently reduced IOP and such effects were absent in P2Y<jats:sub>1<\/jats:sub> receptor\u2010deficient (P2Y<jats:sub>1<\/jats:sub>KO) mice. P2Y<jats:sub>1<\/jats:sub> receptors were functionally expressed in the ciliary body, trabecular meshwork and Schlemm's canal. Activation of P2Y<jats:sub>1<\/jats:sub> receptors negatively regulated aquaporin 4 (AQP4) function but up\u2010regulated endothelial NOS (eNOS). P2Y<jats:sub>1<\/jats:sub>KO mice showed chronic ocular hypertension regardless of age. P2Y<jats:sub>1<\/jats:sub>KO mice at 3\u00a0months old showed no damage to retinal ganglion cells, whereas 12\u2010month\u2010old mice showed a significant loss of these cells and impairment of ocular functions. Damage to retinal ganglion cells was attenuated by chronic administration of an IOP\u2010reducing agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>Activation of P2Y<jats:sub>1<\/jats:sub> receptors reduced IOP via dual pathways including AQP4 and eNOS. Loss of P2Y<jats:sub>1<\/jats:sub> receptors resulted in glaucomatous optic neuropathy, suggesting that P2Y<jats:sub>1<\/jats:sub> receptors might provide an effective target in the treatment of glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15637","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T09:03:10Z","timestamp":1627290190000},"page":"4552-4571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Loss of P2Y<sub>1<\/sub> receptors triggers glaucoma\u2010like pathology in mice"],"prefix":"10.1111","volume":"178","author":[{"given":"Kentaro","family":"Hamada","sequence":"first","affiliation":[{"name":"Department of Neuropharmacology Interdisciplinary Graduate School of Medicine, University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youichi","family":"Shinozaki","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology Interdisciplinary Graduate School of Medicine, University of Yamanashi  Yamanashi Japan"},{"name":"GLIA Center Interdisciplinary Graduate School of Medicine, University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Namekata","sequence":"additional","affiliation":[{"name":"Visual Research Project Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Ultrastructural Research National Institute of Physiological Sciences  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Ohno","sequence":"additional","affiliation":[{"name":"Division of Ultrastructural Research National Institute of Physiological Sciences  Aichi Japan"},{"name":"Department of Anatomy Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Segawa","sequence":"additional","affiliation":[{"name":"Center for Life Science Research, Interdisciplinary Graduate School of Medicine, University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Interdisciplinary Graduate School of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Harada","sequence":"additional","affiliation":[{"name":"Visual Research Project Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schuichi","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology Interdisciplinary Graduate School of Medicine, University of Yamanashi  Yamanashi Japan"},{"name":"GLIA Center Interdisciplinary Graduate School of Medicine, University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14747"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22695"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-007-9076-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/7741"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5115"},{"key":"e_1_2_12_7_1","first-page":"3728","article-title":"ATP level in the aqueous humor of primary open\u2010angle glaucoma","volume":"59","author":"Chen S.","year":"2018","journal-title":"ARVO Annual Meeting Abstract"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.2.996"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1273-15.2015"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.764571"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.06.013"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00171028"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/21224"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210201200109"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1205750"},{"key":"e_1_2_12_16_1","first-page":"804","article-title":"Endothelial nitric oxide synthase polymorphisms and susceptibility to high\u2010tension primary open\u2010angle glaucoma in an Egyptian cohort","volume":"20","author":"Emam W. A.","year":"2014","journal-title":"Molecular Vision"},{"issue":"719","key":"e_1_2_12_17_1","first-page":"1","article-title":"Changes in P2Y purinergic receptor expression in the ciliary body in a murine model of glaucoma","volume":"8","author":"Fonseca B.","year":"2017","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16548"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1181"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30178"},{"issue":"705","key":"e_1_2_12_21_1","first-page":"1","article-title":"Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA\/2J mice","volume":"9","author":"Harder J. M.","year":"2018","journal-title":"Cell Death & Disease"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0567"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23218"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44646"},{"issue":"76","key":"e_1_2_12_26_1","first-page":"1","article-title":"Deficiency of complement component 5 ameliorates glaucoma in DBA\/2J mice","volume":"10","author":"Howell G. R.","year":"2013","journal-title":"Journal of Neuroinflammation"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2016.0090"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-1576-4"},{"issue":"19640","key":"e_1_2_12_29_1","first-page":"1","article-title":"Effects of K\u2010115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells","volume":"6","author":"Kaneko Y.","year":"2016","journal-title":"Scientific Reports"},{"issue":"143359","key":"e_1_2_12_30_1","first-page":"1","article-title":"Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin","volume":"6","author":"Kasetti R. B.","year":"2021","journal-title":"JCI Insight"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican1209-84"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7113"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834448100"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4682"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8399"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.06.020"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_12_38_1","first-page":"240","article-title":"Nitric oxide synthase\u20102 in human optic nerve head astrocytes induced by elevated pressure in vitro","volume":"119","author":"Liu B.","year":"2001","journal-title":"Archives of Ophthalmology"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.12.013"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3796"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.10.040"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01586.x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.223354"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.7174"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi068"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.023549"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-00567"},{"issue":"6593","key":"e_1_2_12_48_1","first-page":"1","article-title":"Development and characterization of a new rat ocular hypertension model induced by intracameral injection of conjunctival fibroblasts","volume":"9","author":"Nakagawa A.","year":"2019","journal-title":"Scientific Reports"},{"key":"e_1_2_12_49_1","first-page":"956","article-title":"Nitrovasodilators as a new class of ocular hypotensive agents","volume":"260","author":"Nathanson J. A.","year":"1992","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"82","key":"e_1_2_12_50_1","first-page":"1","article-title":"Phosphorylation\u2010dependent regulation of mammalian Aquaporins","volume":"8","author":"Nesverova V.","year":"2019","journal-title":"Cell"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(99)00010-7"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2003.07.005"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2006"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2001896117"},{"issue":"7","key":"e_1_2_12_55_1","first-page":"1","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert N.","year":"2020","journal-title":"PLoS Biology"},{"key":"e_1_2_12_56_1","first-page":"1060","article-title":"Increased levels of extracellular ATP in glaucomatous retinas: Possible role of the vesicular nucleotide transporter during the development of the pathology","volume":"21","author":"Perez de Lara M. J.","year":"2015","journal-title":"Molecular Vision"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.4.494"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.08.036"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.10.1667"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.36.741"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.10.037"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2014.0067"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1199"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.052860"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3020-06.2006"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14817"},{"issue":"93456","key":"e_1_2_12_68_1","first-page":"1","article-title":"Purinergic dysregulation causes hypertensive glaucoma\u2010like optic neuropathy","volume":"2","author":"Shinozaki Y.","year":"2017","journal-title":"JCI Insight"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20118"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.085274"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5300.668"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13427"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2488"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470030069026"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.02.012"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2001250117"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.145"},{"issue":"117242","key":"e_1_2_12_78_1","first-page":"1","article-title":"Correlation between mouse age and human age in anti\u2010tumor research: Significance and method establishment","volume":"242","author":"Wang S.","year":"2020","journal-title":"Life Sciences"},{"issue":"232","key":"e_1_2_12_79_1","first-page":"1","article-title":"Nicotinamide and WLD(S) act together to prevent neurodegeneration in glaucoma","volume":"11","author":"Williams P. A.","year":"2017","journal-title":"Frontiers in Neuroscience"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal0092"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.227983"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-0122-z"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.20028597"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.45881"},{"key":"e_1_2_12_85_1","first-page":"36","article-title":"Single nucleotide polymorphisms of metabolic syndrome\u2010related genes in primary open angle glaucoma","volume":"3","author":"Zhou G.","year":"2010","journal-title":"International Journal of Ophthalmology"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-012-9309-4"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.15637","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/bph.15637","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T17:27:52Z","timestamp":1693243672000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.15637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,6]]},"references-count":85,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/bph.15637"],"URL":"https:\/\/doi.org\/10.1111\/bph.15637","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,6]]},"assertion":[{"value":"2021-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}