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However, FDA\u2010approved GLP\u20101 receptor agonists are often accompanied by nausea and emesis and, in some lean T2DM patients, by undesired anorexia. Importantly, the hypophagic and emetic effects of GLP\u20101 receptor agonists are caused by activation of central GLP\u20101 receptors. This review summarizes two different approaches to mitigate the incidence and severity of nausea and emesis related to GLP\u20101 receptor agonists: conjugation with vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      , or related corrin ring\u2010containing compounds (\u2018corrination\u2019), and development of dual agonists of GLP\u20101 receptors with glucose\u2010dependent insulinotropic polypeptide (GIP). Such approaches could lead to the generation of GLP\u20101 receptor agonists with improved therapeutic efficacy, thus decreasing treatment attrition, increasing patient compliance and extending treatment to a broader population of T2DM patients. The data reviewed show that it is possible to pharmacologically separate the emetic effects of GLP\u20101 receptor agonists from their glucoregulatory action.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.4\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.4\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15647","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T22:58:56Z","timestamp":1628290736000},"page":"542-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Glucagon\u2010like peptide\u20101 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?"],"prefix":"10.1111","volume":"179","author":[{"given":"Tito","family":"Borner","sequence":"first","affiliation":[{"name":"Department of Biobehavioral Health Sciences University of Pennsylvania, School of Nursing  Philadelphia Pennsylvania USA"},{"name":"Department of Psychiatry University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C.","family":"Tinsley","sequence":"additional","affiliation":[{"name":"Department of Chemistry Syracuse University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Chemistry Syracuse University  Syracuse New York USA"},{"name":"Department of Medicine State University of New York Upstate Medical University  Syracuse New York USA"},{"name":"Department of Pharmacology State University of New York Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health Sciences University of Pennsylvania, School of Nursing  Philadelphia Pennsylvania USA"},{"name":"Department of Psychiatry University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C.","family":"De Jonghe","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health Sciences University of Pennsylvania, School of Nursing  Philadelphia Pennsylvania USA"},{"name":"Department of Psychiatry University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4131-3"},{"issue":"987","key":"e_1_2_9_3_1","first-page":"e986","article-title":"Glucose\u2010dependent insulinotropic polypeptide receptor\u2010expressing cells in the hypothalamus regulate food intake","volume":"30","author":"Adriaenssens A. 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