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This study aimed to repurpose praziquantel to treat psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Psoriasis\u2010like skin inflammation was induced in mice (C57 and Balb\/C) by topical application of imiquimod or intradermal injection of recombinant IL\u201023. Praziquantel was either orally or topically administered during the psoriasis induction period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Mice treated with either oral or topical praziquantel exhibited markedly improved psoriasiform skin symptoms when compared with control mice, as judged by disease severity score, epidermal thickening, inflammatory cell infiltration and spleen size. Flow cytometric analysis of infiltrating immune cells from mouse skin displayed reduced infiltration of Th17 cells. In vitro experiments revealed that praziquantel inhibited STAT3 phosphorylation and ROR\u03b3t expression in splenic CD4<jats:sup>+<\/jats:sup> T\u2010cells. Praziquantel also decreased STAT3 phosphorylation in HEK\u2010A\/F cells. Down\u2010regulation of STAT3 phosphorylation in these cells accounts for the decreased number of Th17 cells and keratinocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>These results provide the first preclinical evidence that praziquantel may effectively treat psoriasis, and suggest that praziquantel alleviates symptoms in mice by inhibiting STAT3 phosphorylation, thereby suppressing Th17 immune responses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15652","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T14:23:09Z","timestamp":1628346189000},"page":"4726-4740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Repurposing the anthelmintic praziquantel to treat psoriasis"],"prefix":"10.1111","volume":"178","author":[{"given":"Lihua","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Chonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuancheng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Chonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ju","family":"Bae","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chonbuk National University  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung\u2010Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Chonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14750"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14751"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14752"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"S1","article-title":"The Concise Guide to PHARMACOLOGY 2019\/20: Other protein targets","volume":"176","author":"Alexander S. 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