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Benzodiazepines are potential therapeutic candidates, as microdialysis and voltammetry studies have shown that they can decrease dopamine concentrations in the nucleus accumbens of rodents and block the increase in dopamine levels and appetitive 50\u2010kHz ultrasonic vocalizations (USVs) induced by amphetamine in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      Here, we tested whether administration of 2.5\u2010mg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      diazepam (i.p.) in adult male rats could block the effects of 20\u2010mg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      cocaine (i.p.) on electrically evoked phasic dopamine signals in the nucleus accumbens measured by fast\u2010scan cyclic voltammetry, as well as 50\u2010kHz USV and locomotor activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Cocaine injection increased evoked dopamine signals up to threefold within 5\u2009min, and the increase was significantly higher than baseline for at least 75\u2009min. The injection of diazepam, 5\u2009min after cocaine, attenuated the cocaine effect by nearly 50%, and this attenuation was maintained for at least 40\u2009min. Behaviourally, cocaine increased the number of appetitive 50\u2010kHz calls by about 12\u2010fold. Diazepam significantly blocked this effect for the entire duration of the session. Also, cocaine\u2010treated rats were more active than controls and diazepam significantly attenuated cocaine\u2010induced locomotion, by up to 50%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>These results suggest that the neurochemical and psychostimulant effects of cocaine can be mitigated by diazepam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue on Building Bridges in Neuropharmacology. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.8\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.8\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15658","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T02:37:30Z","timestamp":1628822250000},"page":"1565-1577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diazepam attenuates the effects of cocaine on locomotion, 50\u2010kHz ultrasonic vocalizations and phasic dopamine in the nucleus accumbens of rats"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7723-0064","authenticated-orcid":false,"given":"William 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