{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:52:56Z","timestamp":1792648376093,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730094"],"award-info":[{"award-number":["81730094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91853125"],"award-info":[{"award-number":["91853125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773584"],"award-info":[{"award-number":["81773584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21977118"],"award-info":[{"award-number":["21977118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20202009"],"award-info":[{"award-number":["BK20202009"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Psoriasis is a chronic inflammatory skin disease associated with both innate and adaptive immune responses. The stimulator of interferon genes (STING) protein engages in sensing of cytosolic DNA to initiate dsDNA\u2010driven immune responses. In vitro and in vivo anti\u2010psoriasis effects of STING antagonist H\u2010151 were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>We analysed the gene expression profile of STING and related downstream targets in the skin samples of healthy people and psoriasis patients from the GEO database. Cellular inhibitory activity of H\u2010151 on STING pathway was confirmed via qPCR and western blotting. The preventive effect of topical application of H\u2010151 on imiquimod\u2010induced psoriatic mice was examined through histological, immunohistochemical, immunofluorescent, flow cytometric analysis, ELISA Kits and other approaches. Preliminary mechanistic studies were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Gene expressions of STING and its downstream target were up\u2010regulated in lesional skin samples from psoriasis patients. Topical administration of H\u2010151 attenuated the skin lesions in imiquimod\u2010induced psoriatic mouse model, while the secretion of pro\u2010inflammatory cytokines (IL\u201017, IL\u201023 and IL\u20106), infiltration of M1 macrophages and differentiation of Th17 cells were significantly suppressed by H\u2010151 treatment. Mechanistically, H\u2010151 inhibited STING\/NF\u2010\u03baB signalling in both keratinocytes and immune cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>H\u2010151 displayed anti\u2010inflammatory activity in both keratinocytes and immune cells, and decreased the severity of psoriatic response in vivo. Inhibition of STING signalling pathway may represent a novel therapeutic approach to psoriasis and related complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15673","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T10:17:10Z","timestamp":1630318630000},"page":"4907-4922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["The STING antagonist H\u2010151 ameliorates psoriasis via suppression of STING\/NF\u2010\u03baB\u2010mediated inflammation"],"prefix":"10.1111","volume":"178","author":[{"given":"Yanhong","family":"Pan","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"You","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmacy of Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibang","family":"Sui","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoliang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiping","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoan","family":"Wen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Dai","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-7674","authenticated-orcid":false,"given":"Hongbin","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing China"},{"name":"State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmacy of Guangxi Normal University  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14752"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14747"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14392"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13258"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"issue":"3","key":"e_1_2_12_8_1","first-page":"889","article-title":"Psoriasis, mental disorders and stress","volume":"33","author":"Biljan D.","year":"2009","journal-title":"Collegium Antropologicum"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.022"},{"issue":"3","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2340\/0001555572165168","article-title":"Interleukin\u20106 in normal skin and psoriasis","volume":"72","author":"Castells\u2010Rodellas A.","year":"1992","journal-title":"Acta Dermato\u2010Venereologica"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45211"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302120"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14153"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002001"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.07.034"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.036"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.01.010"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018447"},{"issue":"4","key":"e_1_2_12_19_1","first-page":"799","article-title":"Dysfunction of regulatory T cells mediated by AKT\u2010FOXO1 signaling pathway occurs during the development of psoriasis","volume":"13","author":"Fan Z.","year":"2020","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15610"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6367"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0287-8"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.012"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15357"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201800282"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07317"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00640-08"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.399"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.11.005"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2020.09.023"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12477880"},{"issue":"1","key":"e_1_2_12_34_1","first-page":"12","article-title":"Role of regulatory T cells in psoriasis pathogenesis and treatment","volume":"184","author":"Nussbaum L.","year":"2020","journal-title":"British Journal of Dermatology"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051566"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.05.024"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4763"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/964069"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07975-2"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00466"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1824624"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900850106"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03704.x"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01308-2"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016295"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13831"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/949317"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1932"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_648_19"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2566"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8652"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.020"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.09.003"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.01.008"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.15673","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T10:05:34Z","timestamp":1692957934000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.15673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,30]]},"references-count":55,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/bph.15673"],"URL":"https:\/\/doi.org\/10.1111\/bph.15673","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,30]]},"assertion":[{"value":"2021-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}