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Despite decades of research, treatment options are sparse or missing, and relapse rates are high. Glucagon\u2010like peptide 1 (GLP\u20101) is released in the small intestine, promotes blood glucose homeostasis, slows gastric emptying and reduces appetite. GLP\u20101 receptor agonists approved for treating Type 2 diabetes mellitus and obesity have received attention as a potential anti\u2010addiction treatment. Studies in rodents and non\u2010human primates have demonstrated a reduction in intake of alcohol and drugs of abuse, and clinical trials have been initiated to investigate whether the preclinical findings can be translated to patients. This review will give an overview of current findings and discuss the possible mechanisms of action. We suggest that effects of GLP\u20101 in alcohol and substance use disorders is mediated centrally, at least partly through dopamine signalling, but precise mechanisms are still to be uncovered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.4\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.4\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15677","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T23:30:58Z","timestamp":1631835058000},"page":"625-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":257,"title":["The role of glucagon\u2010like peptide 1 (GLP\u20101) in addictive disorders"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9300-470X","authenticated-orcid":false,"given":"Mette Kruse","family":"Klausen","sequence":"first","affiliation":[{"name":"Psychiatric Centre Copenhagen, Rigshospitalet, 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