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This study investigated the positive effects of fenofibrate on dystrophic muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Myostatin expression in serum and muscle tissue from patients with Duchenne muscular dystrophy and <jats:italic>mdx<\/jats:italic> mice were tested. Primary myoblasts isolated from <jats:italic>mdx<\/jats:italic> mice were challenged with an inflammatory stimulus and treated with fenofibrate. In animal experiments, 6\u2010week\u2010old male <jats:italic>mdx<\/jats:italic> mice were treated with fenofibrate (100\u2009mg kg<jats:sup>\u20101<\/jats:sup>) administered orally once per day for 6\u00a0weeks. Effects of fenofibrate were evaluated by tests of muscle function plus histology and biochemical analyses of serum. Expression of myostatin, MuRF1, and atrogin\u20101 in skeletal muscle was evaluated by western blotting and real\u2010time PCR. Total and oxidative myosin heavy chain (MHC) were assessed via immunofluorescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Expression of myostatin protein was increased in dystrophic muscle of patients with Duchenne muscular dystrophy and <jats:italic>mdx<\/jats:italic> mice. Fenofibrate enhanced myofibre differentiation by down\u2010regulating the expression of myostatin protein but not mRNA in primary myoblasts of <jats:italic>mdx<\/jats:italic> mice. Fenofibrate significantly improved muscle function while ameliorating muscle damage in <jats:italic>mdx<\/jats:italic> mice. These benefits were accompanied by an anti\u2010inflammatory effect. Fenofibrate treatment returned myofibre function by inhibiting the expressions of myostatin, MuRF1, and atrogin\u20101 protein in the gastrocnemius muscle and diaphragm, while leaving the mRNA level of myostatin unaffected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>Fenofibrate substantially slows muscle dystrophy by promoting the degradation of myostatin protein, which may indicate a new therapeutic focus for patients with Duchenne muscular dystrophy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15678","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T03:24:59Z","timestamp":1632367499000},"page":"1237-1250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A new therapeutic effect of fenofibrate in Duchenne muscular dystrophy: The promotion of myostatin 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