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ESL <jats:italic>in vivo<\/jats:italic> efficacy was investigated in the 6\u2010Hz psychomotor seizure model in both <jats:italic>Kcnq2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> and <jats:italic>Kcnq2<\/jats:italic><jats:sup>+\/+<\/jats:sup> mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>S\u2010Lic increased the amplitude and decreased the incidence of physiological sharp wave\u2013ripples in a concentration\u2010dependent manner and slightly decreased gamma oscillations frequency. 4\u2010Aminopyridine\u2010evoked seizure\u2010like events were blocked at high S\u2010Lic concentrations and substantially reduced in incidence at lower concentrations. These results were not different in <jats:italic>Kcnq2<\/jats:italic><jats:sup>+\/+<\/jats:sup> and <jats:italic>Kcnq2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice, although the EC<jats:sub>50<\/jats:sub> estimation implicated higher efficacy in <jats:italic>Kcnq2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>animals. <jats:italic>In vivo<\/jats:italic>, <jats:italic>Kcnq2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice had a lower seizure threshold than <jats:italic>Kcnq2<\/jats:italic><jats:sup>+\/+<\/jats:sup> mice. In both genotypes, ESL dose\u2010dependently displayed protection against seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>S\u2010Lic slightly modulates hippocampal oscillations and blocks epileptic activity <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Our results suggest that the increased excitability in <jats:italic>Kcnq2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice is effectively targeted by S\u2010Lic high concentrations, presumably by blocking diverse sodium channel subtypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15689","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T03:56:51Z","timestamp":1633406211000},"page":"84-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>In vitro<\/i> and <i>in vivo<\/i> anti\u2010epileptic efficacy of eslicarbazepine acetate in a mouse model of <i>KCNQ2<\/i>\u2010related self\u2010limited epilepsy"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9513-6378","authenticated-orcid":false,"given":"Laura","family":"Monni","sequence":"first","affiliation":[{"name":"Clinical and Experimental Epileptology, Department of Neurology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"NeuroCure Clinical Research Centre Berlin Institute of Health at Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Kraus","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Epileptology, Department of Neurology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Life Sciences Institute, Department of Cellular and Physiological Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-1823","authenticated-orcid":false,"given":"Matthias","family":"Dipper\u2010Wawra","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Epileptology, Department of Neurology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Epilepsy\u2010Center Berlin\u2010Brandenburg Institute for Diagnostics of Epilepsy  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-5078","authenticated-orcid":false,"given":"Patricio","family":"Soares\u2010da\u2010Silva","sequence":"additional","affiliation":[{"name":"Division of Research and Development BIAL \u2013 Portela &amp; CA S. 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