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Multiple 5\u2010HT receptor subtypes contribute to a variety of region\u2010specific functional effects. The raph\u00e9 nuclei control nociceptive inputs by releasing 5\u2010HT in the brainstem, whereas dural mast cells provide the humoral source of 5\u2010HT in the meninges. Triptans (5\u2010HT\n                      <jats:sub>1B\/D<\/jats:sub>\n                      agonists) and ditans (5\u2010HT\n                      <jats:sub>1F<\/jats:sub>\n                      agonists) are the best established 5\u2010HT anti\u2010migraine agents. However, activation of meningeal afferents via ionotropic 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      receptors results in long\u2010lasting excitatory drive suggesting a pro\u2010nociceptive role for these receptors in migraine. Nevertheless, clinical data do not clearly support the applicability of currently available 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      antagonists to migraine treatment. The reasons for this might be the presence of 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      receptors on inhibitory interneurons dampening the excitatory drive, a lack of 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      A\u2013E subunit\u2010selective antagonists and gender\/age\u2010dependent effects. This review is focusing on the controversial role of 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      receptors in migraine pathology and related pharmacological perspectives of 5\u2010HT ligands.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue on Advances in Migraine and Headache Therapy (BJP 75th Anniversary). To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.3\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.3\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15710","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:29:41Z","timestamp":1634146181000},"page":"400-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["5\u2010hydroxytryptamine in migraine: The puzzling role of ionotropic 5\u2010HT\n                    <sub>3<\/sub>\n                    receptor in the context of established therapeutic effect of metabotropic 5\u2010HT\n                    <sub>1<\/sub>\n                    subtypes"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-6280","authenticated-orcid":false,"given":"Rashid","family":"Giniatullin","sequence":"first","affiliation":[{"name":"A.I. 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