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However, the widespread clinical use of currently available MRAs in cardiorenal medicine is hampered by an increased risk of hyperkalaemia. The mineralocorticoid receptor (MR) is a nuclear receptor responsible for fluid and electrolyte homeostasis in epithelial tissues, whereas pathophysiological MR activation in nonepithelial tissues leads to undesirable pro\u2010inflammatory and profibrotic effects. Therefore, new strategies that selectively target the deleterious effects of the MR but spare its physiological function are needed. In this review, we discuss recent pharmacological developments starting from novel non\u2010steroidal MRAs, such as finerenone or esaxerenone, that are now entering clinical use, to concepts arising from the current knowledge of the MR signalling pathway, aiming at receptor\u2013coregulator interaction, epigenetics or downstream effectors of the MR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue on Emerging Fields for Therapeutic Targeting of the Aldosterone\u2010Mineralocorticoid Receptor Signaling Pathway. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.13\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.13\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15719","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T06:23:40Z","timestamp":1635229420000},"page":"3235-3249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Approaches towards tissue\u2010selective pharmacology of the mineralocorticoid receptor"],"prefix":"10.1111","volume":"179","author":[{"given":"Dorien","family":"Clarisse","sequence":"first","affiliation":[{"name":"Department of Biomolecular Medicine Ghent University  Ghent Belgium"},{"name":"Translational Nuclear Receptor Research 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