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Currently available steroidal MRAs are efficacious in reducing morbidity and mortality; however, they can be associated with intolerable side effects including hyperkalaemia in everyday clinical practice. Recently, a new class of non\u2010steroidal MRAs (including esaxerenone, AZD9977, apararenone, KBP\u20105074 and finerenone) have been developed with an improved benefit\u2013risk profile and a novel indication for finerenone for diabetic kidney disease. To better understand the non\u2010steroidal MRAs, this review provides information on the molecular pharmacology as well as relevant current preclinical and clinical data on cardiorenal outcomes. A comparative review of all compounds in the class is discussed with regard to clinical efficacy and safety as well as a perspective outlining their future use in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue on Emerging Fields for Therapeutic Targeting of the Aldosterone\u2010Mineralocorticoid Receptor Signaling Pathway. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.13\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v179.13\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15747","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T22:37:43Z","timestamp":1637620663000},"page":"3220-3234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":170,"title":["Novel non\u2010steroidal mineralocorticoid receptor antagonists in cardiorenal disease"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-0990","authenticated-orcid":false,"given":"Ulrich","family":"Kintscher","sequence":"first","affiliation":[{"name":"Institute of Pharmacology, Cardiovascular\u2010Metabolic\u2010Renal Research Center Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George L.","family":"Bakris","sequence":"additional","affiliation":[{"name":"Department of Medicine, American Heart Association Comprehensive Hypertension Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-7528","authenticated-orcid":false,"given":"Peter","family":"Kolkhof","sequence":"additional","affiliation":[{"name":"Research &amp; Early Development, Cardiovascular Research Bayer AG  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa736"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)32135\u2010X"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15540"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13347"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002187"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.657957"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.06.015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.234765"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.11.028"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037703"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17073"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15199"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503713"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2025845"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10081"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193380"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310985"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201200081"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101755.2000.00965.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.48"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001854"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007004.pub3"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000084"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.16966\/12470\u201011009.16137"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.16966\/12470\u201011009.16143"},{"issue":"10","key":"e_1_2_12_27_1","article-title":"Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease","author":"Chung E. 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