{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:03Z","timestamp":1787013963504,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T00:00:00Z","timestamp":1644019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>The small molecule BGP\u201015 has been reported to alleviate symptoms of heart failure and improve muscle function in murine models. Here, we investigated the acute and chronic effects of BGP\u201015 in a rabbit model of atherosclerotic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Rabbits were maintained on standard chow (control) or atherogenic diet (hypercholesterolemic) for 16\u2009weeks. BGP\u201015 was administered intravenously (once) or orally (for 16\u2009weeks), to assess acute and chronic effects. Cardiac function was evaluated by echocardiography, endothelium\u2010dependent vasorelaxation was assessed and key molecules in the protein kinase G (PKG) pathway were examined by enzyme\u2010linked immunosorbent assay (ELISA) and western blot. Passive force generation was investigated in skinned cardiomyocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Both acute and chronic BGP\u201015 treatments improved the diastolic performance of the diseased heart. However, vasorelaxation and serum lipid markers were unaffected. Myocardial cyclic guanosine monophosphate (cGMP) levels were elevated in the BGP\u201015\u2010treated group, along with preserved PKG activity and increased phospholamban Ser16\u2010phosphorylation. PDE5 expression decreased in the BGP\u201015\u2010treated group and PDE1 was inhibited. Cardiomyocyte passive tension reduced in BGP\u201015\u2010treated rabbits, the ratio of titin N2BA\/N2B isoforms increased and PKG\u2010dependent N2B\u2010titin phosphorylation elevated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>BGP\u201015 treatment improves diastolic function, reduces cardiomyocyte stiffness and restores titin compliance in a rabbit model of atherosclerotic cardiomyopathy by increasing the activity of the cGMP\u2010PKG pathway. As BGP\u201015 has been proven to be safe, it may be clinically useful in the treatment of diastolic dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15749","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T23:55:30Z","timestamp":1637625330000},"page":"2240-2258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nicotinic\u2010acid derivative BGP\u201015 improves diastolic function in a rabbit model of atherosclerotic cardiomyopathy"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5818-4557","authenticated-orcid":false,"given":"Daniel","family":"Priksz","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Lampe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpad","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Forschung und Lehre (IFL), Department of Molecular and Experimental Cardiology Ruhr University Bochum  Bochum Germany"},{"name":"Department of Cardiology, St. Josef\u2010Hospital and Bergmannsheil Ruhr University Bochum  Bochum Germany"},{"name":"Institute of Physiology Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Herwig","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Forschung und Lehre (IFL), Department of Molecular and Experimental Cardiology Ruhr University Bochum  Bochum Germany"},{"name":"Department of Cardiology, St. Josef\u2010Hospital and Bergmannsheil Ruhr University Bochum  Bochum Germany"},{"name":"Institute of Physiology Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariann","family":"Bombicz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tician","family":"Wilisicz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Szilvassy","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head\u2010Neck Surgery University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko","family":"Posa","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Gesztelyi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Raduly","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reka","family":"Szekeres","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8253-879X","authenticated-orcid":false,"given":"Marcel","family":"Sieme","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Forschung und Lehre (IFL), Department of Molecular and Experimental Cardiology Ruhr University Bochum  Bochum Germany"},{"name":"Department of Cardiology, St. Josef\u2010Hospital and Bergmannsheil Ruhr University Bochum  Bochum Germany"},{"name":"Institute of Physiology Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Papp","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Toth","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazha","family":"Hamdani","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Forschung und Lehre (IFL), Department of Molecular and Experimental Cardiology Ruhr University Bochum  Bochum Germany"},{"name":"Department of Cardiology, St. Josef\u2010Hospital and Bergmannsheil Ruhr University Bochum  Bochum Germany"},{"name":"Institute of Physiology Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Szilvassy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bela","family":"Juhasz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15542"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.1530"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.048520"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24030586"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.193326"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00095"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-015-0175-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd5020022"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14443"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10980"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm079"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300105"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00240"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-017-0799-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109213.10461.F6"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12959"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.08.008"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140919086"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa123"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt144"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201306077"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-016-0814-x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.184408"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306325"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.301286"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1128142"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1151"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.711"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220707"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12491"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25020429"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19102882"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw107"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300268"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-7-56"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6705"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1252-8"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-12-22"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy038"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.02.009"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.076075"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-016-0810-1"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00660.2001"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.931451"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.942250"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2004.10.007"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.07.013"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-020-00742-0"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc1202.105290"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.15749","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.15749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T20:08:05Z","timestamp":1692821285000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.15749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,5]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/bph.15749"],"URL":"https:\/\/doi.org\/10.1111\/bph.15749","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,5]]},"assertion":[{"value":"2021-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}