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Several structural features underlie the development of diabetic cardiomyopathy and eventual diabetes\u2010induced heart failure. Pathological cardiac fibrosis (interstitial and perivascular), in addition to capillary rarefaction and myocardial apoptosis, are particularly noteworthy. Sex differences in the incidence, development and presentation of diabetes, heart failure and interstitial myocardial fibrosis have been identified. Nevertheless, therapeutics specifically targeting diabetes\u2010associated cardiac fibrosis remain lacking and treatment approaches remain the same regardless of patient sex or the co\u2010morbidities that patients may present. This review addresses the observed anti\u2010fibrotic effects of newer glucose\u2010lowering therapies and traditional cardiovascular disease treatments, in the diabetic myocardium (from both preclinical and clinical contexts). Furthermore, any known sex differences in these treatment effects are also explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue on Translational Advances in Fibrosis as a Therapeutic Target. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v180.22\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v180.22\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.15820","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T07:15:33Z","timestamp":1645082133000},"page":"2916-2933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Current challenges in the treatment of cardiac fibrosis: Recent insights into the sex\u2010specific differences of glucose\u2010lowering therapies on the diabetic heart: IUPHAR Review 33"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-0168","authenticated-orcid":false,"given":"Abhipree","family":"Sharma","sequence":"first","affiliation":[{"name":"Heart 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