{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:47:16Z","timestamp":1793371636144,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["JLSCZD2019\u2010065"],"award-info":[{"award-number":["JLSCZD2019\u2010065"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20200201378JC"],"award-info":[{"award-number":["20200201378JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970576"],"award-info":[{"award-number":["81970576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Evidence indicates that ferroptosis plays a key role in acute kidney injury induced by cisplatin. The Nrf2\/NRF2 pathway regulates oxidative stress, lipid peroxidation and positively regulates cisplatin\u2010induced acute kidney injury, but its effect along with the alkaloid leonurine, found in motherwort, on ferroptosis after such acute kidney injury remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      The anti\u2010ferroptotic effects of Nrf2 and leonurine were assessed in a mouse model of cisplatin\u2010induced acute kidney injury.\n                      <jats:italic>In vitro<\/jats:italic>\n                      , the effects of leonurine on erastin\u2010 and RSL3\u2010induced HK\u20102 human PTEC ferroptosis were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Nrf2 deletion induced ferroptosis\u2010related protein expression and iron accumulation\n                      <jats:italic>in vivo<\/jats:italic>\n                      , aggravating cisplatin\u2010induced acute kidney injury. Leonurine activated Nrf2 and prevented iron accumulation, lipid peroxidation and ferroptosis\n                      <jats:italic>in vitro<\/jats:italic>\n                      , being abolished in siNrf2\u2010treated cells. Moreover, leonurine potently inhibited cisplatin\u2010induced renal damage, as assessed by of serum creatinine, blood urea nitrogen, kidney injury molecule\u20101 and NGAL. Importantly, leonurine activated the Nrf2 antioxidative pathway and preventing changes in ferroptosis\u2010related morphological and biochemical indicators, malondialdehyde level, SOD and GSH depletion, and GPX4 and xCT down\u2010regulation, in cisplatin\u2010induced acute kidney injury. Nrf2 KO mice were more susceptible to ferroptosis after cisplatin\u2010induced acute kidney injury than control mice. The protective effects of leonurine on acute kidney injury and ferroptosis were largely abolished in Nrf2 KO mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>These data suggest that renal protective effects of Nrf2 activation on cisplatin\u2010induced acute kidney injury are achieved, at least partially, by inhibiting lipid peroxide\u2010mediated ferroptosis, highlighting the potential of leonurine in acute kidney injury treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15834","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T19:53:41Z","timestamp":1647633221000},"page":"3991-4009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":188,"title":["Leonurine alleviates ferroptosis in cisplatin\u2010induced acute kidney injury by activating the Nrf2 signalling pathway"],"prefix":"10.1111","volume":"179","author":[{"given":"Jianqiang","family":"Hu","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine The First Hospital of Jilin University  Changchun 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