{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:00:23Z","timestamp":1793750423426,"version":"4.6.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017444","name":"Science Fund for Distinguished Young Scholars of Xinjiang Autonomous Region","doi-asserted-by":"publisher","award":["2022D01E17"],"award-info":[{"award-number":["2022D01E17"]}],"id":[{"id":"10.13039\/100017444","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015310","name":"Natural Science Foundation of Xinjiang","doi-asserted-by":"publisher","award":["2021D01C255"],"award-info":[{"award-number":["2021D01C255"]}],"id":[{"id":"10.13039\/501100015310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632022PY05"],"award-info":[{"award-number":["2632022PY05"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Psoriasis is an inflammatory skin disease of chronic recurrence mediated by the interaction between IL\u201017 and keratinocytes, which sustains a vicious circle of inflammation. Safe and effective natural medicine is a potential strategy for the clinical treatment of psoriasis. Given its prominent anti\u2010proliferative and anti\u2010inflammatory properties, we investigated the actions of allicin in improving psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Pharmacodynamic studies were carried out in mice after topical administration of allicin against psoriasis\u2010like lesions induced by imiquimod. Skin sensitization tests were evaluated on guinea pigs. Toxicological studies and skin irritation tests were assessed by consecutive topical allicin alone on the skin of rabbits. RNA\u2010seq probed transcriptomic changes following allicin. Western blot explored the actions of allicin on the interaction between IL\u201017A and keratinocytes. Changes in inflammatory factor expression were analysed by qPCR and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Allicin significantly improved the epidermal structure by inhibiting the excessive proliferation and reduced apoptosis of keratinocytes. Furthermore, allicin reduced the secretion of inflammatory cytokines (IL\u201017A\/F, IL\u201022, IL\u201012, and IL\u201020), chemokines (CXCL2, CXCL5, and CCL20), and anti\u2010bacterial peptides (S100a8\/9). Mechanistically, allicin directly inhibited the IL\u201017\u2010induced TRAF6\/MAPK\/NF\u2010\u03baB and STAT3\/NF\u2010\u03baB signalling cascades in keratinocytes, thus breaking the positive inflammatory feedback and alleviating imiquimod\u2010induced psoriasis\u2010like dermatitis in mice. Importantly, topical administration of allicin did not cause skin allergy, and the safety and adaptability of long\u2010term application were verified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Interfering with IL\u201017 signalling in keratinocytes with allicin is a promising strategy for treating psoriasis, given its safety and effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.15983","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T13:28:18Z","timestamp":1668086898000},"page":"628-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Allicin ameliorates imiquimod\u2010induced psoriasis\u2010like skin inflammation via disturbing the interaction of keratinocytes with 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