{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:54:24Z","timestamp":1792270464729,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006319","name":"Centre National pour la Recherche Scientifique et Technique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022108","name":"Universit\u00e9 de Poitiers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201015\u2010CE37\u20100010"],"award-info":[{"award-number":["ANR\u201015\u2010CE37\u20100010"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Incubation of craving, the progressive increase in drug seeking over the first weeks of abstinence, is associated with temporal changes during abstinence in the activity of several structures involved in drug\u2010seeking behaviour. Decreases of dopamine (DA) release and DA neuronal activity (hypodopaminergic state) have been reported in the ventral tegmental area (VTA) during cocaine abstinence, but the mechanisms underlying these neuroadaptations are not well understood. We investigated the potential involvement of a VTA inhibiting circuit (basolateral amygdala [BLA]\u2013ventral pallidum [VP] pathway) in the hypodopaminergic state associated with abstinence from chronic cocaine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>In a model of cocaine self\u2010administration, we performed in vivo electrophysiological recordings of DA VTA neurons and BLA neurons from anaesthetised rats during early and protracted abstinence and evaluated the involvement of the BLA\u2013VP pathway using a pharmacological approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>We found significant decreases in VTA DA population activity and significant increases in BLA activity after protracted but not after short\u2010term abstinence from chronic cocaine. The decrease in VTA DA activity was restored by pharmacological inhibition of the activity of either the BLA or the VP, suggesting that these regions exert a negative influence on DA activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>Our study sheds new lights on neuroadaptations occurring during incubation of craving leading to relapse. In particular, we describe the involvement of the BLA\u2013VP pathway in cocaine\u2010induced decreases of DA activity in the VTA. This study adds important information about the specific brain network dysfunctions underlying hypodopaminergic activity during abstinence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.16034","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T18:17:12Z","timestamp":1673893032000},"page":"1819-1831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The amygdala\u2013ventral pallidum pathway contributes to a hypodopaminergic state in the ventral tegmental area during protracted abstinence from chronic cocaine"],"prefix":"10.1111","volume":"180","author":[{"given":"Ad\u00e9lie","family":"Salin","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Poitiers, INSERM, U\u20101084, Laboratoire des Neurosciences Exp\u00e9rimentales et Cliniques Poitiers France"},{"name":"Universit\u00e9 de Rennes, Institut Numecan INRAE, INSERM Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Dugast","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, INSERM, U\u20101084, Laboratoire des Neurosciences Exp\u00e9rimentales et Cliniques Poitiers France"},{"name":"CHU de Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Lardeux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, INSERM, U\u20101084, Laboratoire des Neurosciences Exp\u00e9rimentales et Cliniques Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Solinas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, INSERM, U\u20101084, Laboratoire des Neurosciences Exp\u00e9rimentales et Cliniques Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-8657","authenticated-orcid":false,"given":"Pauline","family":"Belujon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, INSERM, U\u20101084, Laboratoire des Neurosciences Exp\u00e9rimentales et Cliniques Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15698"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15539"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addicn.2022.100029"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05896.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.04.014"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx056"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.191"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.022"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.16.4.456"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12452"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.238"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.09.006"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.09.020"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.05.014"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.1.11"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15868"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00482-3"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.05.026"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0507-4"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04915.2001"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1103"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.11.1789"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/35084134"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12627"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00010"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90422-8"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14188"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086176"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21983"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3877"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.302"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.23.1.155"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03178.x"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.1.124"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3664"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90347-6"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12955"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(96)02270-X"},{"key":"e_1_2_13_41_1","first-page":"101","volume-title":"International review of neurobiology","author":"Melis M.","year":"2005"},{"key":"e_1_2_13_42_1","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12848","article-title":"Cocaine and chronic stress exposure produce an additive increase in neuronal activity in the basolateral amygdala","volume":"26","author":"Munshi S.","year":"2019","journal-title":"Addiction Biology"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2007.08.013"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.05.047"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12490"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.4.1350"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0384-15.2015"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00324.2002"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.02.008"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyaa096"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.018"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.10.038"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.09.038"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24381"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00466"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00013"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyw060"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-10-04066.1992"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.08.017"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91327-B"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033808"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890100307"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00739.2007"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.16034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.16034","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.16034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T20:51:25Z","timestamp":1701723085000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.16034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":63,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/bph.16034"],"URL":"https:\/\/doi.org\/10.1111\/bph.16034","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,22]]},"assertion":[{"value":"2022-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}