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Mitochondrial impairment is linked to synaptic dysfunction in normal ageing and age\u2010associated neurodegenerative ailments, including Parkinson's disease (PD) and Alzheimer's disease (AD). Both proteolysis and mitophagy perform a major role in neuroprotection, by maintaining a healthy mitochondrial population during ageing. Mitophagy, a highly evolutionarily conserved cellular process, helps in the clearance of damaged mitochondria and thereby maintains the mitochondrial and metabolic balance, energy supply, neuronal survival and neuronal health. Besides the maintenance of brain homeostasis, hippocampal mitophagy also helps in synapse formation, axonal development, dopamine release and long\u2010term depression. In contrast, defective mitophagy contributes to ageing and age\u2010related neurodegeneration by promoting the accumulation of damaged mitochondria leading to cellular dysfunction. Exercise, stress management, maintaining healthy mitochondrial dynamics and administering natural or synthetic pharmacological compounds are some of the strategies used for neuroprotection during ageing and age\u2010related neurological diseases. The current review discusses the impact of defective mitophagy in ageing and age\u2010associated neurodegenerative conditions, the underlying molecular pathways and potential therapies based on recently elucidated mitophagy\u2010inducing strategies.<\/jats:p>","DOI":"10.1111\/bph.16062","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T19:40:01Z","timestamp":1676490001000},"page":"1542-1561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Mitophagy: A promising therapeutic target for neuroprotection during ageing and age\u2010related diseases"],"prefix":"10.1111","volume":"180","author":[{"given":"Ela","family":"Mishra","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study, Department of Zoology, Institute of Science Banaras Hindu University  Varanasi 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