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In this review, we will focus on target\u2010based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the <jats:italic>Plasmodium<\/jats:italic> lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. 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