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This process is comparable in biological impact to phosphorylation and mediates a variety of signalling events. Unlike conventional neurotransmitters, H\n                      <jats:sub>2<\/jats:sub>\n                      S cannot be stored in vesicles due to its gaseous nature. Instead, it is either locally synthesized or released from endogenous stores. Sulfhydration affords both specific and general neuroprotective effects and is critically diminished in several neurodegenerative disorders. Conversely, some forms of neurodegenerative disease are linked to excessive cellular H\n                      <jats:sub>2<\/jats:sub>\n                      S. Here, we review the signalling roles of H\n                      <jats:sub>2<\/jats:sub>\n                      S across the spectrum of neurodegenerative diseases, including Huntington's disease, Parkinson's disease, Alzheimer's disease, Down syndrome, traumatic brain injury, the ataxias, and amyotrophic lateral sclerosis, as well as neurodegeneration generally associated with ageing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue Recent Innovations in Targeting Redox Biology for Therapeutics. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v183.1\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v183.1\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.16170","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T09:44:01Z","timestamp":1687254241000},"page":"83-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Hydrogen sulfide signalling in neurodegenerative diseases"],"prefix":"10.1111","volume":"183","author":[{"given":"Sunil Jamuna","family":"Tripathi","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwarna","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Miller","sequence":"additional","affiliation":[{"name":"Brain Health Medicines Center, Harrington Discovery Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Pieper","sequence":"additional","affiliation":[{"name":"Brain Health Medicines Center, Harrington Discovery Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"},{"name":"Department of Psychiatry Case Western Reserve University  Cleveland Ohio USA"},{"name":"Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center; Cleveland  Ohio USA"},{"name":"School of Medicine, Institute for Transformative Molecular Medicine Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Pathology, School of Medicine Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-6103","authenticated-orcid":false,"given":"Bindu D.","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"The Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Lieber Institute for Brain Development  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511810112"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15540"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15542"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15543"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15539"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00402"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.154"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0143-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11041154"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/47.8.1500"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705710104"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2764"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108581"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.3.371"},{"key":"e_1_2_9_18_1","first-page":"123","article-title":"Rotorua, hydrogen sulphide and Parkinson's disease\u2010a possible beneficial link?","volume":"130","author":"Cakmak Y. 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