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As the beneficial and therapeutic effects of H\n                      <jats:sub>2<\/jats:sub>\n                      S in pathophysiology, such as in cardiovascular and neurodegenerative diseases, have emerged, so too has the drive for the development of H\n                      <jats:sub>2<\/jats:sub>\n                      S\u2010releasing compounds (aka donors) and their therapeutic applications. Most reported donor compounds singularly release H\n                      <jats:sub>2<\/jats:sub>\n                      S through biocompatible triggers. An emerging area in the field is the development of compounds that can co\u2010deliver H\n                      <jats:sub>2<\/jats:sub>\n                      S with other drugs or biologically relevant species, such as reactive oxygen and nitrogen species (ROS and RNS, respectively). These H\n                      <jats:sub>2<\/jats:sub>\n                      S\u2010based dual donors and hybrid drugs are expected to offset negative side effects from individual treatments or achieve synergistic effects rendering them more clinically effective. Additionally, considering that molecules exist and interact physiologically, dual donors may more accurately mimic biological systems as compared to single donors and allow for the elucidation of fundamental chemistry and biology. This review focuses on the recent advances in the development of H\n                      <jats:sub>2<\/jats:sub>\n                      S\u2010based dual donors and hybrid drugs along with their design principles and synergistic effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue Recent Innovations in Targeting Redox Biology for Therapeutics. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v183.1\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v183.1\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.16211","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:35:12Z","timestamp":1691541312000},"page":"70-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hydrogen sulfide: Recent development of its dual donors and hybrid drugs"],"prefix":"10.1111","volume":"183","author":[{"given":"Shi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Chemistry Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-5000","authenticated-orcid":false,"given":"Meg","family":"Shieh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-6103","authenticated-orcid":false,"given":"Bindu D.","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Sciences The Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"The Solomon H. 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