{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:57:47Z","timestamp":1787504267484,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["ID1187989"],"award-info":[{"award-number":["ID1187989"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Pulmonary arterial hypertension (PAH), a rare fatal disorder characterised by inflammation, vascular remodelling and vasoconstriction. Current vasodilator therapies reduce pulmonary arterial pressure but not mortality. The G\u2010protein coupled formyl peptide receptors (FPRs) mediates vasodilatation and resolution of inflammation, actions possibly beneficial in PAH. We investigated dilator and anti\u2010inflammatory effects of the FPR biased agonist compound 17b in pulmonary vasculature using mouse precision\u2010cut lung slices (PCLS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>PCLS from 8\u2010week\u2010old male and female C57BL\/6 mice, intrapulmonary arteries were pre\u2010contracted with 5\u2010HT for concentration\u2013response curves to compound 17b and 43, and standard\u2010of\u2010care drugs, sildenafil, iloprost and riociguat. Compound 17b\u2010mediated relaxation was assessed with FPR antagonists or inhibitors and in PCLS treated with TNF\u2010\u03b1 or LPS. Cytokine release from TNF\u2010\u03b1\u2010 or LPS\u2010treated PCLS\u2009\u00b1\u2009compound 17b was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Compound 17b elicited concentration\u2010dependent vasodilation, with potencies of iloprost\u2009&gt;\u2009compound 17b\u2009=\u2009riociguat\u2009&gt;\u2009compound 43\u2009=\u2009sildenafil. Compound 17b was inhibited by the FPR1 antagonist cyclosporin H but not by soluble guanylate cyclase, nitric oxide synthase or cyclooxygenase inhibitors. Under inflammatory conditions, the efficacy and potency of compound 17b were maintained, while iloprost and sildenafil were less effective. Additionally, compound 17b inhibited secretion of PAH\u2010relevant cytokines via FPR2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Vasodilation to compound 17b but not standard\u2010of\u2010care vasodilators, is maintained under inflammatory conditions, with additional inhibition of PAH\u2010relevant cytokine release. This provides the first evidence that targeting FPR, with biased agonist, simultaneously targets vascular function and inflammation, supporting the development of FPR\u2010based pharmacotherapy to treat PAH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue Therapeutic Targeting of G Protein\u2010Coupled Receptors: hot topics from the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 2021 Virtual Annual Scientific Meeting. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v181.14\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v181.14\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.16231","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:35:25Z","timestamp":1693614925000},"page":"2287-2301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The small\u2010molecule formyl peptide receptor biased agonist, compound 17b, is a vasodilator and anti\u2010inflammatory in mouse precision\u2010cut lung slices"],"prefix":"10.1111","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5020-6013","authenticated-orcid":false,"given":"William 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